基于VOSviewer的肌少症动物模型研究可视化分析

A Visual Analysis on Animal Model of Sarcopenia Based on VOSviewer

目的分析肌少症动物模型研究的现状、热点及发展趋势,为肌少症动物模型研究提供方向与基础资料。方法检索Web of Science(WOS)核心合集数据库中1900-01-01至2022-12-31的肌少症动物模型研究英文文献,以及中国知网(CNKI)数据库中1915-2022年的肌少症动物模型研究中文文献。应用文献计量分析软件VOSviewer分析发文量、发文国家/地区、机构、作者、期刊及关键词,以揭示该领域研究的主要国家和机构以及热点和前沿方向。结果从WOS核心合集数据库共检索到肌少症动物模型相关文献2819篇,第1篇文献发表于1995年;美国是肌少症动物模型研究最多的国家,发文量为1105篇;发文机构最多的是美国佛罗里达大学,发文量为69篇;中国香港大学是我国发文量最多的机构,共发文20篇;美国学者Holly V R的发文量最多,发表50篇;肌少症动物模型研究刊文量最多的学术期刊是美国的FASEB Journal,刊文量为196篇。CNKI数据库共检索到文献423篇,中文发文量最多的作者是李柱一,共发文19篇。WOS检索文献的关键词共现聚类分析发现,肌少症动物模型研究的热点可概括为肌少症与代谢相关性研究,肌少症动物模型细胞学及再生医学研究,肌少症动物模型与骨、肌肉和神经研究,以及肌少症与运动治疗研究。CNKI数据库检索发现失神经性肌少症模型研究最为广泛,中药对肌少症的作用研究也多有报告。文献阅读发现肌少症动物模型主要包括自然衰老模型、遗传修饰模型、高脂饮食诱导模型、失用性肌少症模型、激素诱导模型及其他疾病复合性的肌少症模型。结论肌少症动物模型是近年来国内外研究的一个热点,文献计量分析在研究方向及热点、模式动物选择、动物模型制作、国内外交流与合作等方面可为肌少症动物模型研究提供基础。

Objective Analyze the current situation,hotspots and development trends of sarcopenia animal model to provide research direction and basic information for sarcopenia animal model research.Methods English literature of research on animal models of sarcopenia was retrieved from the Web of Science core data(WOS)set from 1900-01-01 to 2022-12-31.Chinese literature related to animal models of sarcopenia was retrieved from CNKI database between 1915 and 2022.The bibliometric analysis software VOSviewer was used to explore the countries,orgonizations,authors,hotspots and frontier directions in these studies.Results A total of 2819 articles on animal models of sarcopenia were retrieved from WOS core database.The first paper was published in 1995.The United States has the largest number of animal model studies of sarcopenia with 1105 articles.The institution with the most published articles is the University of Florida in the United States,with 69 articles.The University of Hong Kong has the highest number of publications in China,with 20 articles.American author Van Remmen H,with 50 publications,is the author of the most articles.The journal with the largest number of articles published on animal models of sarcopenia is the American journal called FASEB Journal,with 196 articles.In total,423 articles on animal models of sarcopenia were retrieved from the CNKI database.Author LI Zhuyi has published 19 articles,and is the author of the most articles in China.The keyword co-occurrence clustering analysis of WOS literature search found that the research focus on animal model of sarcopenia can be summarized as the correlation between sarcopenia and metabolism,cytology and regenerative medicine of sarcopenia animal models,the study of sarcopenia animal models in bone,muscle,nerve and exercise therapy.The retrieval results of CNKI database revealed that the most extensive research was about on the model of denervated sarcopenia,and researches on the effects of Chinese medicine on sarcopenia were also widely reported.Through reading the full articles or abstracts of the literature,the animal models of sacopenia mainly include natural aging model,genetic modification model,high-fat diet induction model,disuse model,hormone induction model and complex sarcopenia models of other diseases.Conclusion In recent years,the study on animal model of sarcopenia has become a hotspot at home and abroad.The bibliometric analysis provides a basis for the research of animal models of sarcopenia in terms of research direction,hotspots,model animal selection,animal model making,and domestic and international communication and cooperation.