清热扶正通腑汤联合美罗培南治疗脓毒症的临床效果

Clinical Effect of Qingre Fuzheng Tongfu Decoction Combined with Meropenem in the Treatment of Sepsis

目的:分析清热扶正通腑汤联合美罗培南治疗脓毒症的效果。方法:选取2020年8月—2022年8月北京中医药大学房山医院重症医学科收治的脓毒症患者60例为研究对象。2020年8月—2021年8月收治的患者为单药组,2021年9月—2022年8月收治的患者为联合组,各30例。单药组在常规治疗基础上应用注射用美罗培南,联合组在单药组基础上进行清热扶正通腑汤治疗。比较两组病情严重程度、恢复状况、胃肠道功能、总有效率及病死率。结果:用药后,联合组急性生理及慢性健康状况系统Ⅱ评分低于单药组,差异有统计学意义(P<0.001);联合组ICU治疗时间及住院时间均短于单药组,差异有统计学意义(P<0.001);用药后,联合组二胺氧化酶及D-乳酸水平低于单药组,差异有统计学意义(P<0.001);联合组治疗总有效率高于单药组,28 d病死率低于单药组,差异有统计学意义(P<0.05)。结论:清热扶正通腑汤联合美罗培南用药方案可显著改善脓毒症患者胃肠道功能,促使其病情好转,降低病死率。

Objective:To analyze the effect of Qingre Fuzheng Tongfu Decoction combined with meropenem in the treatment of sepsis.Methods:Sixty patients with sepsis admitted to the Department of Critical Care Medicine of Fangshan Hospital of Beijing University of Chinese Medicine from August 2020 to August 2022 were selected for the study.The patients admitted from August 2020 to August 2021 were in the single-drug group,and the patients admitted from September 2021 to August 2022 were in the combination group,thirty cases each.The single-drug group was treated with meropenem injection on the basis of conventional treatment,and the combination group was treated with Qingre Fuzheng Tongfu Decoction on the basis of the single-drug group.The two groups were compared in terms of severity of disease,recovery status,gastrointestinal function,total effective rate and death rate.Results:After medication,the acute physiological and chronic health status system II scores of the combination group were lower than those of the single-drug group,and the difference was statistically significant(P<0.001);The ICU treatment time and hospitalization time of the combination group were shorter than that of the single-drug group,and the difference was statisti⁃cally significant(P<0.001);After medication,the levels of diamine oxidase and D-lactate in the combination group were lower than those in the single-drug group,and the difference was statistically significant(P<0.001);The total effective rate of treatment in the combination group was higher than that in the single-drug group,and the 28-day morbidity and mortality rate was lower than that in the single-drug group,with a statistically significant difference(P<0.05).Conclusion:The combination of Qingre Fu⁃zheng Tongfu Decoction and meropenem can significantly improve the gastrointestinal function of patients with sepsis,promote the improvement of their condition,and reduce the morbidity and mortality rate.