抗癌活性钛双齿配合物的环糊精负载研究

Research on Cyclodextrin Loading of Anticancer Active Titanium Bicentate Complex

通过Mannich反应制备了ONNO型双酚二氨基配体,并与钛酸异丙酯反应制备了具有抗癌活性的双齿七配位钛配合物,利用高分辨质谱和核磁共振对已合成的配合物进行了表征。通过对此类钛配合物进行了环糊精的包裹研究,对环糊精-钛配合物的纯化及结构鉴定方法进行了构建,系统分析了包合物的质谱及核磁共振氢谱并通过高效液相分析测定了包合率,为环糊精与金属配合物的载体研究提供新的设计思路。

ONNO-type bisphenol diamino ligand was prepared by Mannich reaction,and the bidentate heptagenate titanium complex with antitumor activity was prepared by reacting with isopropyl titanate.The synthesized complex was characterized by high resolution mass spectrometry and nuclear magnetic resonance.Through the study of cyclodextrin encapsulation of such titanium complexes,the purification and structural identification methods of cyclodextrin-titanium complexes were constructed,the mass spectrometry and hydrogen NMR spectroscopy of the inclusion complexes were systematically analyzed,and the inclusion rate was determined by HPLC,which provided a new design idea for the carrier research of cyclodextrin and metal complexes.