大气颗粒物PM_(2.5)诱导机体损伤相关研究中的代谢组学进展

Progress of Metabolomics in Studies of Injuries Induced by PM_(2.5)

目前,中国大气污染问题仍然普遍存在,细颗粒物(fine particulate matter 2.5,PM_(2.5))是一种空气动力学直径<2.5μm的大气污染物。其较小的粒径赋予其强大的穿透性,可随血液循环到达全身,可以对多种器官和组织造成损伤,因此,探究PM_(2.5)的毒理机制尤为重要。代谢组学作为一种分析代谢物变化的方法在许多研究领域中广泛应用,目前关于PM_(2.5)引起机体代谢物紊乱的相关研究也逐渐得到关注。本文综述了目前PM_(2.5)相关研究中的代谢组学研究进展,总结了PM_(2.5)暴露显著影响的机体代谢通路,分别为脂代谢通路、TCA循环(tricarboxylic acid cycle,TCA cycle)代谢通路、氨基酸代谢通路和核苷酸代谢通路,进一步分析了代谢物变化与PM_(2.5)暴露之间的可能关系,对后续相关的代谢组学研究提出建议和发展方向。

PM_(2.5),particulate matter with an aerodynamic diameter less than 2.5μm,is one of the major air pollutants in China.PM_(2.5) has become a serious public concern because of the nationwide burden and tremendous effects on human health.It can easily penetrate blood circulation and may cause irreversible damages to multiple organs and tissues.The underlying biological mechanisms linking PM_(2.5) with organ/tissue dysfunction or degeneration are of high interest and have reached more attention gradually,especially metabolic disorders.Metabolomics,an emerging technology for analyzing metabolite alterations,is widely used to identify the biological pathways linking PM_(2.5) with diseases.Metabolomics related to PM_(2.5) exposure is well-documented,but the relevant systematic summary is limited.This paper reviewed the progress of metabolomics in studies about PM_(2.5) in decades,and concluded the possible metabolic pathways affected by PM_(2.5),including lipid metabolic pathway,tricarboxylic acid cycle metabolic pathway,amino acid metabolic pathway,and nucleotide metabolic pathway.Based on the current progression about metabolic disorders of PM_(2.5) exposure,this paper then raised suggestions and possible directions for further metabolomics studies about PM_(2.5).