丹参姜黄等中药提取物辅助降血脂功能研究

Study the Reducing Blood Lipid Effect of Salvia miltiorrhiza Turmeric and Other Chinese Herbal Extracts

目的:研究丹参、姜黄等中药提取物对高脂血症大鼠血脂水平的影响。方法:将50只雄性SD大鼠进行随机分组,共分为空白对照组、模型对照组以及3个试验组(丹参姜黄等中药提取物高剂量组、中剂量组、低剂量组),每组10只;空白对照组给予维持饲料,模型对照组及3个试验组均给予高脂饲料,造模成立后,3个试验组连续经口灌胃给予中药提取物31 d,空白及模型对照组均给予纯化水。于造模结束和实验结束时对大鼠进行不禁食眼内眦采血,测定血清中TC、TG、LDL-C、HDL-C水平。结果:与空白对照组相比,模型对照组TC、TG、LDL-C水平均显著升高(P<0.01)。与模型对照组相比,3个试验组的TC、TG水平均显著降低(P<0.05)。结论:丹参姜黄等中药提取物可降低高脂血症大鼠的血脂水平。

Objective:To study the effects of Chinese herbal extracts such as Salvia miltiorrhiza and turmeric on blood lipid levels in hyperlipidemia rats.Method:Fifty male SD rats were randomly grouped,they were divided into blank control group,model control group and three experimental groups(Salvia miltiorrhiza turmeric and other Chinese herbal extracts high dose group,medium dose group,low dose group),10 animals each group;the blank control group was given maintenance diet,the model control group and three experimental groups were given high-fat diet,after the model is established,three experimental groups were given Chinese herbal extract by oral intragastric administration for 31 days,blank control group and model control group were given purified water.At the end of modeling and experiment,the rats were collected from inner canthus without fasting,serum TC,TG,LDL-C,HDL-C levels were determined.Result:Compared with blank control group,the levels of TC,TG and LDL-C in model control group were significantly higher(P<0.01).Compared with the model control group,the levels of TC and TG in three experimental groups were significantly lower(P<0.05).Conclusion:The extracts of Salvia miltiorrhiza turmeric and other Chinese herbal can reduce the blood lipid level of hyperlipidemia rats.