肺泡巨噬细胞诱导免疫应答对肺组织炎性损伤作用机制的研究进展

Advances in the mechanism of alveolar macrophage-induced immune response to inflammation injury of lung tissue

肺泡巨噬细胞作为专职性抗原提呈细胞,在宿主免疫防御及适应性免疫应答中发挥重要作用。病原体在肺组织定植引起局部感染后,肺泡巨噬细胞可通过其表面的模式识别受体识别并吞噬病原体,严重者可进一步活化,将摄取的抗原物质提呈给适应性免疫细胞,并可根据组织微环境的变化,转化为促炎或抗炎表型,通过释放相关信号因子,促使机体产生一系列免疫应答,诱导肺部炎性损伤及组织的修复。

As specialized antigen-presenting cells,alveolar macrophages play an important role in host immune defense and adaptive immune response.After local infection caused by pathogens which colonize lung tissue,alveolar macrophages can recognize and engulf pathogens through pattern recognition receptors on their surface.In severe cases,the marophages may be further activated to present the ingested antigenic material to adaptive immune cells,and can be converted into a pro-inflammatory or anti-inflammatory phenotype depending on changes in the tissue microenvironment.By releasing relevant signaling factors,immune responses could regulate lung inflammation injury and tissue repair.