纤维支气管镜肺泡灌洗术联合莫西沙星治疗支气管扩张合并肺部感染患者的效果

Effects of fiberoptic bronchoscopy alveolar lavage combined with Moxifloxacin in treatment of patients with bronchiectasis complicated with pulmonary infection

目的:观察纤维支气管镜肺泡灌洗术联合莫西沙星治疗支气管扩张合并肺部感染患者的效果。方法:选取2020年8月至2022年8月该院收治的82例支气管扩张合并肺部感染患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各41例。对照组给予莫西沙星治疗,观察组在对照组基础上联合纤维支气管镜肺泡灌洗术治疗,比较两组临床疗效,治疗前后肺功能指标[呼吸频率(RR)、最大通气量(MVV)、最大呼气流量(MEF)、用力肺活量(FVC)]水平、免疫功能指标[自然杀伤细胞(NK)、C反应蛋白(CRP)、补体C3、补体C4]水平,以及不良反应发生率。结果:观察组治疗总有效率为90.24%,高于对照组的70.73%,差异有统计学意义(P<0.05);治疗后,观察组RR水平低于对照组,MVV、MEF、FVC水平均高于对照组,差异有统计学意义(P<0.05);治疗后,观察组NK、补体C3、补体C4水平均高于对照组,CRP水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:纤维支气管镜肺泡灌洗术联合莫西沙星治疗支气管扩张合并肺部感染患者,可提高临床疗效,改善肺功能和免疫功能,效果优于单纯莫西沙星治疗。

Objective:To observe effects of fiberoptic bronchoscopy alveolar lavage combined with Moxifloxacin in treatment of patients with bronchiectasis complicated with pulmonary infection.Methods:A prospective study was conducted on 82 patients with bronchiectasis complicated with pulmonary infection admitted to this hospital from August 2020 to August 2022.They were divided into control group and observation group according to the random number table method,41 cases in each.The control group was treated with Moxifloxacin,while the observation group was treated with fiberoptic bronchoscopy alveolar lavage on the basis of that of the control group.The clinical efficacy,the lung function index levels[respiratory rate(RR),maximum ventilation volume(MVV),maximum expiratory flow(MEF),forced vital capacity(FVC)],the immune function index levels[natural killer cells(NK),C-reactive protein(CRP),complement C3,complement C4],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 90.24%,which was higher than 70.73%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the RR level of the observation group was lower than that of the control group,the levels of MVV,MEF and FVC were higher than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of NK,complement C3 and complement C4 in the observation group were higher than those in the control group,the level of CRP was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Fiberoptic bronchoscopy alveolar lavage combined with Moxifloxacin in the treatment of the patients with bronchiectasis complicated with pulmonary infection can improve the clinical efficacy,the lung function and the immune function.Moreover,it is superior to single Moxifloxacin treatment.