丁螺环酮联合喹硫平治疗首发精神分裂症患者的效果

Effects of Buspirone combined with Quetiapine in treatment of first-episode schizophrenia

目的:观察丁螺环酮联合喹硫平治疗首发精神分裂症患者的效果。方法:选取2020年3月至2022年2月该院收治的78例首发精神分裂症患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各39例。对照组口服富马酸喹硫平片治疗,观察组在对照组基础上联合盐酸丁螺环酮片治疗。比较两组临床疗效,治疗前后血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、阳性和阴性症状量表(PANSS)评分、认知功能成套测验(MCCB)评分,以及不良反应发生率。结果:观察组治疗总有效率为97.44%(38/39),高于对照组的79.49%(31/39),差异有统计学意义(P<0.05);治疗3个月后,观察组阳性症状、阴性症状、一般精神病理等PANSS各维度评分及血清TNF-α、IL-6水平均低于对照组,MCCB评分高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丁螺环酮联合喹硫平治疗首发精神分裂症患者效果显著,能减轻阳性症状和阴性症状,降低血清炎性因子水平,提升认知功能,效果优于单用喹硫平治疗。

Objective:To observe effects of Buspirone combined with Quetiapine in treatment of patients with first-episode schizophrenia.Methods:A prospective study was conducted on 78 patients with first-episode schizophrenia admitted to this hospital from March 2020 to February 2022.They were divided into control group and observation group according to the random number table method,39 cases in each group.The control group was treated with Quetiapine fumarate tablets orally,while the observation group was treated with Buspirone hydrochloride tablets on the basis of that of the control group.The clinical efficacy,the serum inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]before and after the treatment,the positive and negative symptom scale(PANSS)score,the cognitive function test(MCCB)score,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.44%(38/39),which was higher than 79.49%(31/39)of the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the PANSS scores of positive symptoms,negative symptoms,general psychopathology and the serum TNF-αand IL-6 levels in the observation group were lower than those in the control group,the MCCB score was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Buspirone combined with Quetiapine is effective in the treatment of the patients with first-episode schizophrenia.It can reduce the positive symptoms and the negative symptoms,reduce the levels of inflammatory factors,and improve the cognitive function.Moreover,it is superior to single Quetiapine treatment.