加味清心莲子饮联合常规西药治疗肾病综合征患者的效果

Effects of Modified Qingxin Lianzi decoction combined with conventional western medicine in treatment of patients with nephrotic syndrome

目的:观察加味清心莲子饮联合常规西药治疗肾病综合征患者的效果。方法:选取2019年12月至2021年1月该院收治的106例肾病综合征患者进行前瞻性研究,采用随机数字表法将其分为观察组和对照组各53例。对照组给予常规西药治疗,观察组在对照组基础上联合加味清心莲子饮治疗,比较两组治疗前后生化指标[24 h尿蛋白定量(24hPro)、白蛋白(ALB)、总胆固醇(TC)、三酰甘油(TG)、血肌酐(Scr)、低密度脂蛋白胆固醇(LDL-C)]水平、中医证候积分、临床疗效、不良反应发生率和复发率。结果:治疗后,观察组ALB水平高于对照组,24hPro、TC、TG、Scr、LDL-C水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组神疲乏力、手足心热、面色无华、汗出、大便干结、口干少津等中医证候积分均低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为92.45%(49/53),高于对照组的77.36%(41/53),差异有统计学意义(P<0.05);观察组不良反应发生率为20.75%(11/53),低于对照组的39.62%(21/53),差异有统计学意义(P<0.05);治疗后半年,观察组复发率为4.08%(2/49),低于对照组的17.07%(8/41),差异有统计学意义(P<0.05)。结论:加味清心莲子饮联合常规西药治疗肾病综合征患者可提高治疗总有效率,改善生化指标水平,降低中医证候积分、不良反应发生率和复发率,效果优于单纯常规西药治疗。

Objective:To observe effects of Modified Qingxin Lianzi decoction combined with conventional western medicine in treatment of patients with nephrotic syndrome.Methods:A prospective study was conducted on 106 patients with nephrotic syndrome admitted to the hospital from December 2019 to January 2021.They were divided into observation group and control group by using the random number table method,53 cases in each.The control group was treated with conventional western medicine,while the observation group was treated with modified Qingxin Lianzi decoction on the basis of that of the control group.The levels of biochemical indexes[24h urine protein(24hPro),albumin(ALB),total cholesterol(TC),triglyceride(TG),serum creatinine(Scr),low density lipoprotein cholesterol(LDL-C)],the TCM syndrome score,the clinical efficacy,the incidence of adverse reactions,and the recurrence rate were compared between the two groups before and after the treatment.Results:After the treatment,the ALB level of the observation group was higher than that of the control group,the levels of 24hPro,TC,TG,Scr and LDL-C were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as fatigue,feverishness in palms and soles,lusterless complexion,sweating,dry stool and dry mouth in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 92.45%(49/53),which was higher than 77.36%(41/53)in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 20.75%(11/53),which was lower than 39.62%(21/53)in the control group,and the difference was statistically significant(P<0.05).Half a year after the treatment,the recurrence rate of the observation group was 4.08%(2/49),which was lower than 17.07%(8/41)of the control group,and the difference was statistically significant(P<0.05).Conclusions:Modified Qingxin Lianzi decoction combined with conventional western medicine can improve the total effective rate of treatment,improve the levels of biochemical indexes,and reduce the TCM syndrome scores,the incidence of adverse reactions and the recurrence rate in the patients with nephrotic syndrome.Moreover,it is superior to single conventional western medicine treatment.