氟哌噻吨美利曲辛片联合雷贝拉唑治疗上腹痛综合征的效果分析

Effect analysis of flupentixol and melitracen tablets combined with rabeprazole in the treatment of epigastric pain syndrome

目的研究氟哌噻吨美利曲辛片联合雷贝拉唑治疗上腹痛综合征的效果。方法133例上腹痛综合征患者,根据随机数字编号方法分为观察组(66例)和对照组(67例)。对照组采用使用雷贝拉唑治疗,观察组采用氟哌噻吨美利曲辛片联合雷贝拉唑治疗。比较两组患者临床疗效、不良反应发生情况及治疗前后焦虑、抑郁心理。结果观察组治疗总有效率95.45%显著高于对照组的85.07%,差异有统计学意义(P<0.05)。观察组不良反应发生率9.09%与对照组的7.46%比较,差异无统计学意义(P>0.05)。治疗后,两组汉密尔顿焦虑量表(HAMA)评分和汉密尔顿抑郁量表(HAMD)评分均低于本组治疗前,且观察组HAMA评分(4.63±0.90)分和HAMD评分(5.42±1.06)分均低于对照组的(5.22±0.99)、(6.12±1.17)分,差异有统计学意义(P<0.05)。结论通过氟哌噻吨美利曲辛片联合雷贝拉唑对上腹综合征患者进行治疗,可以在确保安全的基础上提升临床疗效,改善患者的焦虑、抑郁心理,值得推荐。

Objective To study the effect of flupentixol and melitracen tablets combined with rabeprazole in the treatment of epigastric pain syndrome.Methods A total of 133 patients with epigastric pain syndrome were divided into observation group(66 cases)and control group(67 cases)according to random number numbering method.The control group was treated with rabeprazole,and the observation group was treated with flupentixol and melitracen tablets and rabeprazole.The clinical efficacy,occurrence of adverse reactions,anxiety and depression before and after treatment were compared between the two groups.Results The total effective rate of 95.45% in the observation group was significantly higher than that of 85.07% in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 9.09%,and the difference was not statistically significant when compared with that of 7.46%in the control group(P>0.05).After treatment,the Hamilton Anxiety Scale(HAMA)score and Hamilton Depression Scale(HAMD)score in both groups were lower than those before treatment in this group;HAMA score of(4.63±0.90)points and HAMD score of(5.42±1.06)points in the observation group were lower than those of(5.22±0.99)and(6.12±1.17)points in the control group;the differences were statistically significant(P<0.05).Conclusion In the treatment of patients with epigastric pain syndrome,flupentixol and melitracen tablets combined with rabeprazole can improve clinical efficacy while ensuring safety,and improve the anxiety and depression of patients,which is worthy of recommendation.