摘要
目的:探讨丹芪散治疗糖尿病心肌病的临床疗效及相关机制。方法:将60例糖尿病心肌病患者随机分为观察组及对照组各30例,对照组采用常规治疗,观察组在此基础上加用丹芪散治疗,观察两组临床疗效及心功能、炎症指标、MMP-2的变化情况。结果:干预12周后,观察组总有效率为93.33%,高于对照组的75.86%(P<0.05);观察组心功能指标LVEDP、NTproBNP低于对照组(P<0.05),LVEF较对照组升高(P<0.05);炎症指标如IL-18、IL-1β和hs-CRP低于对照组(P<0.05);心肌纤维化指标MMP-2低于对照组(P<0.05)。结论:丹芪散可改善糖尿病心肌病患者临床症状,提高心功能,其机制可能与减轻炎症反应,改善心肌纤维化相关。
Objective:To explore the clinical effect and related mechanism of Danqi San in treating diabetes cardiomyopathy.Methods:Sixty patients with diabetes cardiomyopathy were randomly divided into treatment group(n=30)and control group(n=30),the control group was treated with con‐ventional treatment,while treatment group was treated with Danqi San on the basis of the control group.The effective rate,cardiac function,inflam‐matory index and MMP-2 of the two groups were observed.Results:The overall response rate of treatment group was 93.33%,which was higher than 75.86%that of control group(P<0.05);LVEDP and NT-proBNP of treatment group were lower than those of control group(P<0.05),and LVEF was higher(P<0.05);Inflammatory indicators such as IL-18 and IL-1βand hs-CRP were lower than those of control group(P<0.05),and MMP-2 was lower(P<0.05).Conclusion:Danqi San can improve the clinical symptoms and cardiac function of patients with diabetes cardiomyopathy.The mechanism may be related to reducing inflammatory reaction and inhibiting myocardial fibrosis.
作者
张小朵
邓斌
彭志坚
向乔
ZHANG Xiao-duo;DENG Bin;PENG Zhi-jian;XIANG Qiao(Shenzhen Bao'an District Hospital of Traditional Chinese Medicine,Shenzhen,Guangdong 518100)
出处
《按摩与康复医学》
2023年第11期5-8,共4页
Chinese Manipulation and Rehabilitation Medicine
基金
深圳市宝安区医疗卫生基础研究项目,编号:2020JD531。
关键词
糖尿病心肌病
丹芪散
心室重构
diabetes cardiomyopathy
Danqi San
ventricular remodeling