期刊文献+

妊高症孕妇产褥期感染病原菌和危险因素及胎盘组织PI3K、Akt表达 被引量:2

Pathogens,risk factors for puerperal infections and expressions of PI3K and Akt in placental tissues of pregnant women with pregnancy-induced hypertension
原文传递
导出
摘要 目的探究妊高症孕妇产褥期感染病原菌和危险因素及胎盘组织磷脂酰肌醇3激酶(PI3K)、蛋白激酶B(Akt)表达。方法回顾性分析浙江省丽水市中医院妇产科在2016年8月—2021年8月收治的76例妊高症产妇产褥期临床资料,依据其产褥期是否感染分为感染组26例和非感染组40例,比较两组患者临床资料,分析产褥期感染的危险因素以及与胎盘组织PI3K、Akt表达的关联。结果剖宫产、产后大出血、产程>8 h、胎膜早破、妊娠期糖尿病、产前贫血的妊高症产妇发生产褥期感染的概率更高(P<0.05);产后大出血、产程是产褥期感染的危险因素(P<0.05);感染组产妇PI3K、Akt、哺乳动物雷帕霉素靶蛋白(mTOR)表达均低于非感染组(P<0.05),且微管轻链Ⅰ蛋白3-Ⅱ(LC3-Ⅱ)、自噬相关蛋白7(Atg7)表达及白细胞介素(IL)-6、IL-8、C-反应蛋白(CRP)水平均高于非感染组(P<0.05);PI3K预测产后产褥期感染的敏感性88.46%,特异性85.00%;Akt预测产后产褥期感染的敏感性88.46%,特异性87.50%;mTOR预测产后产褥期感染的敏感性92.31%,特异性92.50%。结论产程、产后大出血是妊高症孕妇产褥期感染的危险因素,且产妇胎盘组织PI3K、Akt表达情况可预测其感染风险。 OBJECTIVE To explore the distribution of pathogens,risk factors for puerperal infections and expressions of phosphatidylinositol-3 kinase(PI3K)and protein kinase B(Akt)in placental tissues of the pregnant women with pregnancy-induced hypertension.METHODS A total of 76 pregnant women with pregnancy-induced hypertension who were treated in obstetrics and gynecology department of Lishui Hospital of TCM from Aug 2016 to Aug 2021 were enrolled in the study,the clinical data of the subjects were retrospectively analyzed.The subjects were divided into the infection group with 26 cases and the non-infection group with 40 cases according to the status of puerperal infection.The clinical data were compared between the two groups,the risk factors for the puerperal infections and their association with the expressions of placental tissue PI3K and Akt were observed.RESULTS The pregnant women with pregnancy-induced hypertension who had cesarean section,postpartum massive hemorrhage,labor stage more than 8 hours,premature rupture of membrane,gestational diabetes mellitus and antenatal anemia were more likely to have puerperal infections(P<0.05).The postpartum massive hemorrhage and labor stage were the risk factors for the puerperal infections(P<0.05).The expression levels of PI3K,Akt and mammalian target of rapamycin(mTOR)of the infection group were lower than those of the non-infection group(P<0.05);the levels of microtubule-associated protein 1 light chain 3-Ⅱ(LC3-Ⅱ),autophagy 7(Atg7),interleukin(IL)-6,IL-8 and C-reactive protein(CRP)of the infection group were significantly higher than those of the non-infection group(P<0.05).The sensitivity of the PI3K was 88.46%in prediction of the postpartum puerperal infections,with the specificity 85.00%;the sensitivity of the Akt was 88.46%in prediction of the postpartum puerperal infections,with the specificity 87.50%;the sensitivity of the mTOR was 92.31%in prediction of the postpartum puerperal infections,with the specificity 92.50%.CONCLUSION Labor process and postpartum massive hemorrhage are the risk factors for the puerperal infections in the pregnant women with pregnancy-induced hypertension.The placental tissue PI3K and Akt can predict the risk of the infections.
作者 严艳燕 汤琼琼 赵艺 汪记情 叶咏菊 YAN Yan-yan;TANG Qiong-qiong;ZHAO Yi;WANG Ji-qing;YE Yong-ju(Lishui Hospital of Traditional Chinese Inedicine,Lishui,Zhejiang 323000,China)
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2023年第13期2047-2051,共5页 Chinese Journal of Nosocomiology
基金 浙江省医药卫生科技计划基金资助项目(2020KYB031)。
关键词 妊娠期高血压 磷脂酰肌醇3激酶 蛋白激酶B 哺乳动物雷帕霉素靶蛋白 自噬通路 产褥期感染 Pregnancy-induced hypertension Phosphatidylinositol-3 kinase Protein kinase B Mammalian target of rapamycin Autophagy pathway Puerperal infection
  • 相关文献

参考文献3

二级参考文献45

  • 1American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy.Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy [J]. Obstet Gynecol, 2013, 122(5):1122-1131.
  • 2Magee LA, Pels A, Helewa M, et al.Canadian Hypertensive Disorders of Pregnancy Working Group. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary[J]. J Obstet Gynaecol Can, 2014, 36(5):416-441.
  • 3Visintin C, Mugglestone MA, Almerie MQ, et al. Management of hypertensive disorders during pregnancy: summary of NICE guidance[J]. BMJ, 2010, 341 :c2207.
  • 4Lowe SA, Bowyer L, Lust K, et al. The SOMANZ Guidelines for the Management of Hypertensive Disorders of Pregnancy 2014[J]. Aust N Z J Obstet Gynaecol, 2015, 55(1):11-16.
  • 5Campos-Outcah D Sr. US Preventive Services Task Force: the gold standard of evidence-based prevention[J]. J Fam Pract, 2005, 54(6):517-519.
  • 6Magee LA, Hdewa M, Momquin JM, et al. Diagnosis, evaluation,and management of the hypertensive disorders of pregnancy[J]. J Obstet Gynaeeol Can, 2008, 30 (Suppl): S1-48.
  • 7Cote AM, Brown MA, Laln E, et al. Diagnostic accuracy of urinary spot protein: creatiniue ratio for proteinuria in hypertensive pregnant women: systematic review[J]. BMJ, 2008, 336(7651): 1003-1006.
  • 8Churchill D, Beevers GD, Meher S, et al, Diuretics for preventing pre-eclampsia[J]. Cochrane Database Syst Rev, 2007, 24 (1):CD004451.
  • 9McCoy S, Baldwin K. Pharmacotherapeutie options for the treatment of preeelampsia[J]. Am J Health Syst Pharm, 2009, 66(4):337-344.
  • 10Duley L, Gfilmezoglu AM, Chou D. Magnesium sulphate versus lytic cocktail for eclampsia[J]. Cochrane Database Syst Rev, 2010, 8(9):CD002960.

共引文献1217

同被引文献22

引证文献2

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部