海藻酸盐复合水凝胶在癌症治疗中的应用进展

Application Progress of Alginate Composite Hydrogels in Cancer Therapy

海藻酸盐复合水凝胶是目前肿瘤药物递送系统材料的研究热点之一。海藻酸盐水凝胶具有良好的生物相容性、可再生的特点,然而天然海藻酸盐水凝胶因降解缓慢、凝胶不稳定等缺点使其在机体环境下可能无法实现预期的结果。海藻酸盐通过结合其他材料,并用离子交联、共价交联和自由基聚合等方法形成水凝胶,使其在癌症治疗中得到广泛应用。本文基于海藻酸盐水凝胶复合体系,综述了海藻酸盐水凝胶结构及其基本性质,重点阐述了近几年来海藻酸盐复合水凝胶在常见癌症治疗应用的研究状况,总结当前研究重点方向并讨论了海藻酸盐复合水凝目前存在问题,为进一步拓展海藻酸盐复合水凝胶在临床癌症治疗的研究提供参考。

Alginate composite hydrogel is one of the research hotspots of tumor drug delivery system materials at present.Alginate hydrogel has good biocompatibility and regeneration properties.However,the natural alginate saline gel may not achieve the expected results in the body environment due to the slow degradation and instability of the gel.Alginate has found extensive application in cancer therapy through its combination with other materials and the utilization of ionic cross-linking,covalent cross-linking,and free radical polymerization to form hydrogels.Based on the composite system of alginate brine gel,this paper summarizes the structure and properties of alginate hydrogel,with a focus on recent research into alginate composite hydrogel in common cancer treatments application,summarizes the current research focus and discuss the existing problems of alginate composite hydrogel,so as to provide reference for further expanding the research of alginate composite hydrogel in clinical cancer treatment.