摘要
Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic structure of coumarin and furan rings.They are commonly found in bioactive natural products and have a diverse range of biological and pharmaceutical properties,including cytotoxicity,photosensitivity,insecticidal,antibacterial,and antifungal activity,among others.The elegant linear/angular tricyclic skeleton and superior pharmacological properties,make them ideal for building and developing advanced biological scaffolds for biomedical applications.As a result,the family of furocoumarins has been the focus of intensive research,and lots of encouraging progress have been achieved in recent years.This review summarizes the most recent methods reported for the synthesis of the furocoumarin derivative family,along with their applications in medicinal chemistry covering from 2018 to 2022.
基金
financial support from the National Natural Science Foundation of China(Nos.21971211 and 22171232)
the Natural Science Foundation of Zhejiang Province(No.2022XHSJJ007)
the Qiantang River Talent Foundation(No.QJD1902029)
Westlake University
supported by Instrumentation and Service Centers for Molecular Science and for Physical Science(ISCMS and ISCPS)
by the Mass Spectrometry&Metabolomics Core Facility at the Center for Biomedical Research Core Facilities and Westlake University HPC Center。
