摘要
Bioorthogonal reactions can take place in biological environments without interfering with biochemical processes.In this study,Pd(PPh_(3))_(2)Cl_(2)was used as a bioorthogonal catalyst to in situ transform the stable N-heterocyclic carbene(NHC)-gold(Ⅰ)-alkyne complex 5 to its active species which can effectively inhibit thioredoxin reductase(TrxR)and exhibit significant anticancer bioactivity in hepatocellular carcinoma(HCC).
基金
the financial supports of the National Natural Science Foundation of China(Nos.82173684 and 82204181)
Nanjing University of Chinese Medicine National Natural Science Foundation of China Counterpart Funding(No.XPT82204181)
General Project of Basic Science in Colleges and Universities of Jiangsu Province(No.21KJB350007)
Jiangsu Provincial Health Commission(No.Z2021057)
the Open Project of Chinese Materia Medica First Class Discipline of Nanjing University of Chinese Medicine(No.2020YLXK010)
the Priority Academic Program Development of Jiangsu Higher Education Institutions(Integration of Chinese and Western Medicine)
the experimental support from the Experiment Center for Science and Technology,Nanjing University of Chinese Medicine
financially supported by the“Innovative and Entrepreneurial Team”Program of Jiangsu Province(2020)。
