曲唑酮与帕罗西汀治疗焦虑症病人睡眠障碍的比较

Comparison of trazodone and paroxetine in treating dyssomnia of anxiety disorder

目的 :比较曲唑酮和帕罗西汀对焦虑症病人睡眠障碍的疗效。方法 :4 5例焦虑症病人随机分为 2组。曲唑酮组 2 2例 ,给予曲唑酮 5 0～ 10 0mg·d- 1,qn× 8wk。帕罗西汀组 2 3例 ,给予帕罗西汀2 0～ 4 0mg·d- 1,qn× 8wk。结果 :睡眠障碍因子评分 :在 1wk时 ,曲唑酮组 3.0±s 1.7,帕罗西汀组4 .0± 1.6 ;在 2wk时 ,曲唑酮组 1.3± 1.2 ,帕罗西汀组 2 .3± 1.3(均P <0 .0 5 )。总睡眠时间 :2组比较在 1wk时差异有非常显著意义 (P <0 .0 1) ;在 2wk时差异有显著意义 (P <0 .0 5 )。早醒现象 :2组比较在 2 ,4wk时差异均有显著意义 (P <0 .0 5 )。睡眠增多、嗜睡不良反应分别为 0 / 2 3,6 / 2 2 (P <0 .0 5 )。结论 :曲唑酮比帕罗西汀改善睡眠见效早、作用快、作用强 ,睡眠时间长 。

AIM: To compare the effect of trazodone vs paroxetine on dyssomnia of anxiety disorder. METHODS: Forty-five patients of anxiety disorder were randomly divided into two groups: trazodone group of tweenty-two patients was treated with trazodone 50-100 mg·d -1,qn×8 wk.Paroxetine group of tweenty-three patients was treated with paroxetine 20-40 mg·d -1,qn×8 wk. RESULTS: Dyssomnia factor grading: 1 wk , trazodone group 3.0±s 1.7, paroxetine group 4.0±1.6;2 wk,trazodone group 1.3±1.2,paroxetine group 2.3± 1.3. There was significant difference between two groups (P<0.05). Total sleeping time : it prolonged more markedly in trazodone group than that in paroxetine group, there was a very significant difference between two groups in 1 wk(P<0.01),and significant difference in 2 wk(P<0.05). Early awakening: it ieduced more markedly in trazodone group than that in paroxetine group ,there is significant difference between two groups in 2 wk and 4 wk(P<0.05).Hypersomnia and somnolence was observed in 0/23,6/22,respectively(P<0.05). CONCLUSIONS: Trazodone's action is stronger, faster, and earlier than paroxetine’s in treating dyssomnia of anxiety disorder,furthermore, it has a longer total sleeping time and lesser early awakening.