卡前列素氨丁三醇注射液、缩宫素注射液联合米索前列醇片治疗妊娠宫缩乏力性产后出血的临床研究

Clinical Study on Carprost Tromethamine Injection, Oxytocin Injection and Misoprostol Tablets for Postpartum Bleeding Caused by Pregnant Uterine Asthenia

目的 探讨治疗妊娠宫缩乏力性产后出血时给予卡前列素氨丁三醇注射液、缩宫素注射液联合米索前列醇片后的效果。方法 选取2021年1月-2022年12月本院收治的66例经阴道分娩发生妊娠宫缩乏力性产后出血的产妇作为研究对象。将采取米索前列醇和缩宫素二联治疗的33例产妇设为对照组,将在对照组的基础上联合卡前列素氨丁三醇进行三联治疗的33例产妇设为观察组,两组比较临床效果、产后2h和24h出血量、出血时间、不良反应发生率。结果 对比两组治疗效果,观察组总有效率优于对照组,差异具有统计学意义(P<0.05)。观察组产后2h和24h出血量、出血时间低于对照组,差异具有统计学意义(P<0.05)。对比两组不良反应发生率,差异不具有统计学意义(P>0.05)。结论 治疗妊娠宫缩乏力性产后出血时,给予卡前列素氨丁三醇注射液、缩宫素注射液联合米索前列醇片,效果显著。

Objective To investigate effect of carboprost tromethamine injection,oxytocin injection and misoprostol tablet in treatment of postpartum bleeding caused by pregnant uterine inertia.Methods The paper collected 66 pregnant women with postpartum bleeding casused by uterine inertia during vaginal delivery in our hospital from January 2021 to December 2022 as analysis objects for retrospective study.33 pregnant women in control group were treated with misoprostol and oxytocin.In addition,33 pregnant women in observation group were treated with carboprost tromethamine on the basis of control group.Clinical effect,amount of bleeding 2 hours and 24 hours after delivery,bleeding time and incidence of adverse reactions was compared between two groups.Results Treatment effect comparison showed,proportion of control group was 27(81.82%),while that of observation group was 32(96.97%).Total effective rate of observation group was higher,difference was statistically significant,P<0.05.Bleeding amount and bleeding time at 2 and 24 hours postpartum showed,control group had(368.51±62.35)ml,(499.58±15.87)ml and(34.18±5.74)min,while observation group had(250.71±58.63)ml,(380.74±12.02)ml and(14.32±2.48)min.Observation group had lower bleeding volume and shorter bleeding time at 2 and 24 hours postpartum,with statistically significant difference(P<0.05).Incidence of adverse reactions between two groups comparison showed,that of control group accounted for 4(12.12%)and that of observation group for 1(3.03%).Difference between two groups was not statistically significant(P>0.05).Conclusion Carprost tromethamine injection,oxytocin injection and misoprostol tablet can achieve significant effect in treatment of pregnant postpartum bleeding caused by uterine inertia,which has some certain promotion value.