尿石素在精神疾病中的神经调节作用及应用前景

The neuroregulatory effects and potential applications of urolithins in mental disorders

精神疾病是一类病因未明、多因素引起的思维、情感、行为以及社交功能的异常状态。随着精神疾病的发病率不断上升,有效的治疗药物却进展缓慢,因此,新药物的开发和应用成为当今研究的热点话题。近年来,尿石素作为一种天然活性物质成分引起了研究人员的广泛关注,它可以通过血脑屏障发挥抗炎、抗氧化应激、抗凋亡等神经保护作用,被认为是调节神经系统的活性小分子,具有潜在的临床应用前景。目前尿石素应用于精神疾病的研究尚未见相关报道。本文对近年来国内外关于尿石素在精神疾病中可能存在的神经调节机制和治疗潜力进行综述,旨在为精神疾病的研究提供新的方向,并为尿石素在精神疾病治疗药物开发和临床转化的科学应用提供新思路。

Mental disorders are a group of complex neurological conditions with unclear etiologies,charac-terized by abnormalities in cognitive,emotional,volitional,and behavioral functions.The prevalence of mental disorders is increasing,whereas the development of effective drugs has been slow,greatly impacting the mental and physical well-being and quality of life in patients.Consequently,the development and application of new drugs have become a hot topic in current research.In recent years,urolithins,as natural bioactive compounds,have garnered widespread attention among researchers.By crossing the blood-brain barrier,urolithins play neuroprotective roles including anti-inflammatory,antioxidant,and anti-apoptotic effects.They are considered potential small mol-ecules for modulating the nervous system,with potential clinical applications for symptom improvement and reha-bilitation in mental disorders.However,no research on the application of urolithins for mental disorders has been currently reported.In this review,we summarize the recent domestic and international research on the neuroregula-tory mechanisms and therapeutic potential of urolithins for mental disorders,aiming to provide new directions for research in mental disorders and offer novel insights for the development and clinical conversion of urolithin-based treatments for mental disorders.