利胆退黄汤治疗非酒精性脂肪性肝病疗效及对患者肝功能、糖脂代谢和血清脂肪因子的影响

Lidan Tuihuang decoction on liver function,glycolipid metabolism,and serum adipose factors in the treatment of non alcoholic fatty liver disease

目的:探究利胆退黄汤治疗非酒精性脂肪性肝病及对患者肝功能、糖脂代谢和血清脂肪因子的影响。方法:将100例非酒精性脂肪性肝病患者随机分为研究组和对照组,每组各50例,对照组餐后口服多烯磷酸酯胆碱胶囊,研究组在对照组基础上联合利胆退黄汤治疗。治疗12周后,比较两组的疗效、中医症候、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、低/高密度脂蛋白胆固醇(LDL-C/HDL-C)、视黄醇结合蛋白-4(RBP-4)、固醇调节元件结合蛋白-1C(SREBP-1C)、瘦素、脂联素及不良反应。结果:治疗后,两组患者的主症评分、次症评分、ALT、AST、FPG、FINS、TC、TG、LDL-C、RBP-4、SREBP-1C、瘦素较治疗前均降低,研究组低于对照组(P<0.05);两组患者的HDL-C、脂联素较治疗前均升高,研究组高于对照组(P<0.05)。研究组患者的治疗有效率高于对照组(P<0.05)。两组均未出现严重不良反应。结论:利胆退黄汤治疗非酒精性脂肪性肝病,有利于调节患者的糖脂代谢功能,改善肝功能,提升疗效。

Objective:To explore the effects of Lidan Tuihuang decoction on liver function,glucose and lipid metabolism,and serum adipose factors in the treatment of non-alcoholic fatty liver disease.Methods:A total of 100 patients with non-alcoholic fatty liver disease were randomly divided into a study group and a control group,with 50 cases in each group.The control group received oral administration of polyene phosphate choline capsules after meals,while the study group received treatment with Lidan Tuihuang decoction on the basis of the control group.After 12 weeks of treatment,the efficacy,TCM syndromes,alanine aminotransferase(ALT),aspartate aminotransferase(AST),fasting blood glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triglyceride(TG),low/high-density lipoprotein cholesterol(LDL-C/HDL-C),retinol binding protein-4(RBP-4),sterol regulatory element binding protein-1C(SREBP-1C),Leptin,adiponectin,and adverse reactions.Results:After treatment,the main syndrome score,secondary syndrome score,ALT,AST,FPG,FINS,TC,TG,LDL-C,RBP-4,SREBP-1C,and leptin of the two groups of patients decreased compared to before treatment,and the study group was lower than the control group(P<0.05).The levels of HDL-C and adiponectin in both groups of patients increased compared to before treatment,and the study group was higher than the control group(P<0.05).The treatment effectiveness rate of the study group patients was higher than that of the control group(P<0.05).Both groups did not experience serious adverse reactions.Conclusion:Lidan Tuihuang decoction is beneficial for regulating the glucose and lipid metabolism function of patients with non-alcoholic fatty liver disease,improving liver function,and enhancing therapeutic effect.