阻塞性睡眠呼吸暂停低通气综合征患者胰岛素抵抗发生机制及治疗研究进展

Research progress of the pathogenesis and treatment of insulin resistance in patients with obstructive sleep apnea hypopnea syndrome

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种常见的慢性疾病,近年来其与2型糖尿病的关系被很多学者关注。胰岛素抵抗是将T2DM与OSAHS联系起来的关键因素。OSAHS的慢性间歇性缺氧和睡眠碎片化激活交感神经系统和下丘脑-垂体-肾上腺轴,引起全身炎症和自噬等,促进胰岛素抵抗的发展,进展为葡萄糖耐量减低,并最终导致T2DM。但OSAHS和胰岛素抵抗之间的具体通路尚不明确,需要进一步研究来验证。本文针对OSAHS患者胰岛素抵抗的发生机制以及治疗措施方面的研究进展做一综述,以期为OSAHS患者胰岛素抵抗的临床和基础研究提供参考。

Obstructive sleep apnea hypopnea syndrome(OSAHS)is a common chronic disease.In recent years,the correlation of OSAHS with type 2 diabetes has attracted many scholars′attention.Insulin resistance is the key factor linking T2DM with OSAHS.Chronic intermittent hypoxia and sleep fragmentation of OSAHS activate the sympathetic nervous system,and hypothalamic-pituitary-adrenal axis,which cause systemic inflammation and autophagy,promote the development of insulin resistance and progress to reduced glucose tolerance,eventually leading to T2DM.However,the evidence on the specific pathway between OSAHS and insulin resistance is insufficient,and further studies are needed to verify it.This article will makes a review on the new research progress in the pathogenesis and treatment of insulin resistance in patients with OSAHS,in order to provide reference for clinical and basic research.