柴桂消瘿汤联合中药透药法外治用于桥本甲状腺炎的效果研究

Study on the effect of Chaigui Xiaoying Decoction combined with transdermal drug delivery of traditional Chinese medicine for Hashimoto thyroiditis

目的分析柴桂消瘿汤联合中药透药法外治用于桥本甲状腺炎的效果。方法78例桥本甲状腺炎患者,采取奇偶分组法分为对照组和观察组,每组39例。对照组患者接受中药透药法外治,观察组患者在对照组基础上接受柴桂消瘿汤治疗。对比两组临床疗效,治疗前后甲状腺激素[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)]水平,治疗前后抗甲状腺蛋白抗体(TG-Ab)和抗甲状腺过氧化物酶抗体(TPO-Ab)水平,治疗前后甲状腺大小。结果观察组的临床总有效率为94.87%,高于对照组的76.92%,差异具有统计学意义(P<0.05)。治疗后,两组患者的FT3、FT4、TSH水平均明显优于治疗前,且观察组的FT3(5.52±1.20)pmol/L、FT4(16.29±1.63)pmol/L、TSH(2.92±0.25)μIU/ml均明显优于对照组的(4.18±1.14)pmol/L、(13.42±3.11)pmol/L、(3.49±0.32)μIU/ml,差异具有统计学意义(P<0.05)。治疗后,两组患者的TPO-Ab、TG-Ab水平均明显低于治疗前,且观察组的TPO-Ab(208.63±18.71)U/ml、TG-Ab(381.27±35.34)U/ml均明显低于对照组的(262.91±24.55)、(411.06±39.53)U/ml,差异具有统计学意义(P<0.05)。治疗后,两组患者的左叶左右径、左叶前后径、右叶左右径和右叶前后径均明显小于治疗前,且观察组的左叶左右径(16.85±1.44)mm、左叶前后径(15.54±1.35)mm、右叶左右径(17.22±1.51)mm和右叶前后径(15.28±1.35)mm均明显小于对照组的(18.21±1.61)、(16.67±1.48)、(18.27±1.62)、(16.42±1.44)mm,差异具有统计学意义(P<0.05)。结论桥本甲状腺炎患者接受柴桂消瘿汤结合中药透药法外治,能使患者的甲状腺功能明显提升,临床治疗效果显著,临床应用价值较高。

Objective To analyze the effect of Chaigui Xiaoying Decoction combined with transdermal drug delivery of traditional Chinese medicine for Hashimoto thyroiditis.Methods A total of 78 patients with Hashimoto thyroiditis were divided into control group and observation group by odd-even grouping method,with 39 cases in each group.Patients in the control group were treated with transdermal drug delivery of traditional Chinese medicine,and patients in the observation group were treated with Chaigui Xiaoying Decoction on the basis of the control group.Both groups were compared in terms of clinical efficacy,the levels of thyroid hormone[free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)]before and after treatment,the levels of thyroglobulin antibody(TG-Ab)and anti-thyroid peroxidase antibody(TPO-Ab)before and after treatment,and the size of thyroid before and after treatment.Results The total clinical effective rate of the observation group was 94.87%,which was higher than that of 76.92%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of FT3,FT4 and TSH in both groups were significantly better than those before treatment in this group;the observation group had FT3 of(5.52±1.20)pmol/L,FT4 of(16.29±1.63)pmol/L and TSH of(2.92±0.25)μIU/ml,which were significantly better than those of(4.18±1.14)pmol/L,(13.42±3.11)pmol/L and(3.49±0.32)μIU/ml in the control group;the differences were statistically significant(P<0.05).After treatment,the levels of TPO-Ab and TG-Ab in both groups were significantly lower than those before treatment in this group;TPO-Ab of(208.63±18.71)U/ml and TG-Ab of(381.27±35.34)U/ml in the observation group were significantly lower than those of(262.91±24.55)and(411.06±39.53)U/ml in the control group;the differences were statistically significant(P<0.05).After treatment,the left-right diameter of left lobe,anterior-posterior diameter of left lobe,right and left-right diameter of right lobe and anterior-posterior diameter of left lobe of both groups were significantly lower than those of this group before treatment;in the observation group,the left-right diameter of left lobe was(16.85±1.44)mm,the anterior-posterior diameter of left lobe was(15.54±1.35)mm,the left-right diameter of right lobe was(17.22±1.51)mm and the anterior-posterior diameter of right lobe was(15.28±1.35)mm,which were significantly lower than those of(18.21±1.61),(16.67±1.48),(18.27±1.62)and(16.42±1.44)mm in the control group;the differences were statistically significant(P<0.05).Conclusion Chaigui Xiaoyin Decoction combined with transdermal drug delivery of traditional Chinese medicine has significant clinical effect for patients with Hashimoto thyroiditis,and can significantly improve the thyroid function,which contains high clinical application value.