胰岛素泵持续强化治疗对妊娠期糖尿病患者血糖控制及新生儿分娩结局效果研究

Effect of Continuous Intensive Insulin Pump Therapy on Blood Glucose Control and Neonatal Delivery Outcome in Patients with Gestational Diabetes Mellitus

目的 探讨胰岛素泵持续强化治疗对妊娠期糖尿病(GDM)患者血糖控制及新生儿分娩结局效果研究。方法 随机数字表法将GDM患者70例分成参照组及观察组,各35例,参照组实施常规胰岛素治疗,观察组实施胰岛素泵持续强化治疗;比较两组空腹血糖(FPG)以及餐后2h血糖(plasma glucose 2 hours after meal,2hPG)控制状况的变化,新生儿分娩总不良结局以及产妇不良事件总发生率。结果 治疗后FPG以及2HPG均减少,观察组比参照组减低更明显(P<0.05)。观察组新生儿分娩总不良结局(14.29%)显著低于参照组(37.14%)(P<0.05)。观察组产妇不良事件总发生率(20.00%)明显低于参照组(42.86%)(P<0.05)。结论 应用胰岛素泵持续强化治疗GDM患者,能有效控制患者血糖,降低新生儿分娩不良结局以及产妇不良事件的发生率。

Objective To investigate the effect of continuous intensive insulin pump therapy on blood glucose control and neonatal delivery outcome in patients with gestational diabetes mellitus(GDM).Methods 70 GDM patients were randomly divided into control group and observation group,35 cases in each group;The control status of fasting plasma glucose(FPG)and plasma glucose 2 hours after meal(2hPG)were compared between the two groups.Results FPG and 2hPG decreased after treatment,and the decrease in observation group was more obvious than that in control group(P<0.05).The total adverse outcome of neonatal delivery in the observation group(14.29%)was significantly lower than that in the control group(37.14%)(P<0.05).The total incidence of adverse events in the observation group(20.00%)was significantly lower than that in the control group(42.86%)(P<0.05).Conclusion Continuous intensive treatment of GDM patients with insulin pump can effectively control blood glucose,reduce the incidence of adverse neonatal outcomes and maternal adverse events.