地西泮联合苯巴比妥治疗小儿发热性惊厥症状控制时长的影响

Influenceof Diazepam Combined with Phenobarbital Treatmenton Symptom Control Duration of Febrile Convulsion in Children

目的 研究地西泮联合苯巴比妥治疗对小儿发热性惊厥的症状控制时长的影响。方法 选取小儿发热性惊厥104例,按照随机法分为联合用药组(n=52)和单一用药组(n=52),单一用药组使用地西泮,联合用药组在此基础上加用苯巴比妥。对比2组疗效、药物起效时长、惊厥改善时长、体温恢复时长、住院时长、心肌酶水平[磷酸肌酸激酶(CK)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CKI)]、脑神经相关因子[神经肽Y(NPY)、神经营养因子(BDNF)]、不良反应发生率变化。结果 联合用药组总有效率94.23%(49/52)较单一用药组73.08%(38/52)高,差异有统计学意义(P<0.05);与单一用药组比较,联合用药组药物起效时长、惊厥改善时长、体温恢复时长、住院时长较短,差异有统计学意义(P<0.05);与单一用药组比较,治疗后联合用药组CK、CKI、LDH水平低,差异有统计学意义(P<0.05);与单一用药组比较,治疗后联合用药组NPY、BDNF水平低,差异有统计学意义(P<0.05);联合用药组不良反应发生率3.85%(2/52)与单一用药组11.54%(6/52)比较差异无统计学意义(P>0.05)。结论地西泮配合苯巴比妥在发热性惊厥患儿中疗效明显,可改善临床症状,调节心肌酶水平和脑神经因子表达,且用药具有安全性,临床可进一步推广及应用。

Objective To study the influence of diazepam combined with phenobarbital treatmenton the symptom control duration of febrile convulsion in children.Methods 104 cases of febrile convulsion in children were selected and randomly divided into a combined drug group(n=52)and a single drug group(n=52).The single drug group used diazepam,and the combined drug group added phenobarbital on this basis.The therapeutic effect,drug onset time,convulsion improvement time,body temperature recovery time,hospitalization time,myocardial enzyme levels[creatinephosphate kinase(CK),lactate dehydrogenase(LDH),creatine kinase isoenzyme(CKI)],brain nerve related factors[neuropeptide Y(NPY),neurotrophic factor(BDNF)]andchanges of adverse reactions occurrence rate of the two groups were compared.Results The total effective rate of the combined drug group 94.23%(49/52)washigher than that of the single drug group 73.08%(38/52),with a statistical difference(P<0.05);Compared with the single drug group,the drug onset time,convulsion improvement time,body temperature recovery time and hospitalization time of the combined drug group were shorter(P<0.05);Compared with the single drug group,the levels of CK,CKI and LDH in the combined drug groupafter treatment were lower,with statistical differences(P<0.05);Compared with the single drug group,the levels of NPY and BDNF in the combined drug groupafter treatment were lower,with statistical differences(P<0.05);There was no significant difference in the incidence of adverse reactions between the combination group 3.85%(2/52)and the single drug group 11.54%(6/52)(P>0.05).Conclusion Diazepam combined with phenobarbital in treating febrile convulsions in childrenhas obvious curative effect.It can improve clinical symptoms,regulate the level of myocardial enzymes and the expression of brain nerve factors,and is safe to use,which can be further promoted and applied in clinical practice.