新生儿按蚊伊丽莎白菌感染研究进展

Progress of neonatal infection with Elizabethkingia anophelis

按蚊伊丽莎白菌(Elizabethkingia anophelis,E.anophelis)是威胁人类健康的重要病原体之一,其作为一种重要的条件致病菌,易出现院内爆发性感染,可引起新生儿尤其是早产儿脑膜炎,严重影响患儿的生命安全和生存质量。E.anophelis具有多重耐药的特性,给临床治疗带来巨大挑战。以往的报道中常将E.anophelis误认为脑膜败血伊丽莎白菌,实际上E.anophelis占伊丽莎白菌属感染的很大一部分,需引起临床医生的重视。该文从E.anophelis流行病学、新生儿感染临床特征、药物敏感性、治疗及预防等方面进行综述,旨在为临床诊疗提供参考。

Elizabethkingia anophelis is one of the most significant pathogens threatening human health.As an important opportunistic pathogen,it is prone to nosocomial infection outbreaks,and can cause neonatal meningitis,especially in prematurity,seriously affecting the safety and quality of life of children.E.anophelis has the characteristic of multi-drug resistance,which brings great challenges to clinical treatment.E.anophelis was commonly misidentified as E.meningosepticum in previous reports.In fact,E.anophelis accounts for a significant proportion of Elizabethkingia infections,which needs more attention.This article reviews the epidemiology of E.anophelis,clinical features of neonatal infection,drug sensitivity,treatment and prevention,in order to provide reference for clinical diagnosis and treatment.