易栓症分子遗传学研究进展

Research progress on molecular genetics of thrombophilia

易栓症是多种遗传或获得性因素导致的容易发生血栓栓塞的疾病或状态,严重影响人们的身体健康。随着分子遗传学方法开始应用于遗传性易栓症相关基因的染色体定位,逐步发现了与其易感性有关的数种基因。现就易栓症相关基因的染色体定位、遗传易感基因及其与种族、地域的关系等作一综述,以期为相关人群易栓症的防治提供参考。

Thrombophilia is a disease or state that is prone to thromboembolism caused by a variety of genetic or acquired factors,which seriously affects people’s health.With the application of molecular genetic methods to the chromosome mapping of genes related to hereditary thromboembolism,several genes related to its susceptibility have been gradually discovered.This article reviews the chromosome location of thrombophilia related genes,genetic susceptibility genes and their relationship with race and region,with a view to providing reference for the prevention and treatment of thrombophilia in related populations.