中医药治疗结节性甲状腺肿机制研究进展

Research Progress on Mechanism of Chinese Medicine in Treating Nodular Goiter

结节性甲状腺肿具有失分化癌变为甲状腺癌的概率,研制出具有针对性的干预措施可降低癌变率或延缓其进展。中医药治疗结节性甲状腺肿有独特优势,作用机制包括诱导细胞凋亡、促进细胞自噬、调节胰岛素抵抗、调节体内细胞因子、调节促甲状腺激素、调节碘含量等。通过归纳中医药治疗本病的相关机制,以期为相关实验研究及临床提供更多的理论依据。

Nodular goiter has the probability of dedifferentiated carcinoma turning into thyroid cancer.The use of targeted interventions can reduce the rate of carcinogenesis or delay its progression.Traditional Chinese medicine has unique advantages in the treatment of nodular goiter.Its mechanism of treatment includes inducing cell apoptosis,promoting cell autophagy,regulating insulin resistance,regulating cytokines in vivo,regulating thyroid-stimulating hormone,regulating iodine content and other aspects.By summarizing the relevant mechanism of TCM treatment of this disease,in order to provide more theoretical basis for relevant experimental research and clinical practice.