献血人群血小板数与铁代谢指标的相关性研究

Relationship between Iron Metabolic Parameters and Platelet Counts in Blood Donors

目的:探讨献血人群中血小板数与铁代谢指标的相关性。方法:收集400例符合单采血小板捐献要求的献血者血液学指标,将献血者分为铁蛋白降低组与正常组,比较两组相关血液学指标的差异,分别分析铁代谢指标、血常规指标与血小板数的相关性。结果:无论男性还是女性,铁蛋白降低组的血小板数均显著高于正常组(P<0.01)。在铁代谢指标中,女性献血者血小板数与血清铁蛋白(SF)、血清铁(SI)和转铁蛋白饱和度(TSAT)均呈负相关(r=-0.162,r=-0.153,r=-0.256),与总铁结合力(TIBC)、不饱和铁结合力(UIBC)呈正相关(r=0.219,r=0.294);男性献血者血小板数与SF、SI和TSAT均呈负相关(r=-0.188,r=-0.148,r=-0.224),与UIBC呈正相关(r=0.220)。血常规指标中,女性献血者血小板数与平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均红细胞血红蛋白浓度(MCHC)和网织红细胞血红蛋白含量(Ret-He)均呈负相关(r=-0.236,r=-0.267,r=-0.213,r=-0.284),男性献血者血小板数与MCH、MCHC和Ret-He均呈负相关(r=-0.184,r=-0.221,r=-0.209)。结论:在C反应蛋白水平较低的献血人群中,铁储备能力越低,铁组织利用率越低,血小板数越趋向增高。

Objective:To investigate the correlation of iron metabolic parameters with platelet counts in blood donors.Methods:A total of 400 blood donors who met requirements of apheresis platelet donation were collected,and their hematological parameters were analyzed.The donors were divided into low ferritin group and normal group,the differences of hematological parameters between the two groups were compared,and the correlation of iron metabolic parameters and routine hematology parameters with platelet counts were analyzed.Results:Whether male or female,low ferritin group had higher platelet counts than normal group(P<0.01).Among the iron metabolic parameters,the platelet counts was negatively correlated with serum ferritin(SF),serum iron(SI),and transferrin saturation(TSAT)(r=-0.162,r=-0.153,r=-0.256),and positively correlated with total iron binding capacity(TIBC)and unsaturated iron binding capacity(UIBC)(r=0.219,r=0.294)in female blood donors.Platelet counts was also negatively correlated with SF,SI and TSAT(r=-0.188,r=-0.148,r=-0.224)and positively correlated with UIBC(r=0.220)in male blood donors.Among the routine hematology parameters,platelet counts was negatively correlated with mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),mean corpuscular hemoglobin concentration(MCHC),and reticulocyte hemoglobin equivalent(Ret-He)in female blood donors(r=-0.236,r=-0.267,r=-0.213,r=-0.284).Platelet counts was also negatively correlated with MCH,MCHC and Ret-He in male blood donors(r=-0.184,r=-0.221,r=-0.209).Conclusion:In blood donors with low C-reactive protein level,the lower the iron store capacity,the lower the iron utilization,and the platelet counts tends to rise.