炎症性肠病与睡眠障碍的双向关系

Two⁃way Relationship Between Inflammatory Bowel Disease and Sleep Disorder

炎症性肠病(IBD)是一种胃肠道特发性炎症性疾病,主要包括克罗恩病(CD)和溃疡性结肠炎(UC)。慢性疾病是睡眠质量的重要影响因素,睡眠质量是评价生命质量的关键指标。睡眠障碍会导致机体出现疲劳、焦虑和压力。活动期IBD患者的睡眠障碍发生率高于缓解期。当IBD患者病情加重时,睡眠障碍加剧,而睡眠障碍又会导致肠道炎症加重、损伤恢复缓慢。本文就睡眠障碍与IBD的相关性研究作一总结,阐明两者之间的双向互作关系,以期为IBD伴睡眠障碍的临床管理和治疗提供参考。

Inflammatory bowel disease(IBD)is an idiopathic inflammatory disease of gastrointestinal tract,which mainly includes Crohn’s disease(CD)and ulcerative colitis(UC).The existence of chronic diseases is an important influencing factor of sleep quality,and sleep quality is a key index to evaluate the quality of life.Sleep disorder can lead to fatigue,anxiety and stress.The incidence of sleep disorder in patients with active IBD is higher than that in remission IBD.When patients with IBD get worse,the sleep disorder is more serious,while sleep disorder can aggravate intestinal inflammation and injury recovery.This article summarized the research on the correlation between sleep disorder and IBD,and clarified their two-way interaction,so as to provide reference for the clinical management and treatment of sleep disorder associated with IBD.