美托洛尔联合贝那普利治疗原发性高血压合并慢性心力衰竭患者的效果

Effects of Metoprolol combined with Benazepril in treatment of patients with primary hypertension complicated with chronic heart failure

目的:观察美托洛尔联合贝那普利治疗原发性高血压合并慢性心力衰竭患者的效果。方法:选取2021年1月至2022年7月该院收治的70例原发性高血压合并慢性心力衰竭患者进行前瞻性研究,按随机数字表法将其分为对照组和观察组各35例。两组均行常规对症治疗,在此基础上,对照组采用贝那普利治疗,观察组在对照组基础上采用美托洛尔治疗。比较两组临床疗效、治疗前后心肌损伤指标[血清成纤维细胞生长因子23(FGF23)、血浆N末端B型脑钠肽前体(NT-proBNP)]水平、心功能指标[左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)]水平、血压和不良反应发生率。结果:观察组治疗总有效率为94.29%(33/35),高于对照组的71.43%(25/35),差异有统计学意义(P<0.05);治疗后,两组收缩压、舒张压、血清FGF23和血浆NTproBNP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组LVEF水平均高于治疗前,且观察组高于对照组,两组LVEDD和LVESD水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:美托洛尔联合贝那普利治疗原发性高血压合并慢性心力衰竭患者可提高治疗总有效率,改善心功能指标水平,降低心肌损伤指标水平和血压,效果优于单纯贝那普利治疗。

Objective:To observe effects of Metoprolol combined with Benazepril in treatment of patients with primary hypertension complicated with chronic heart failure.Methods:A prospective study was conducted on 70 patients with primary hypertension complicated with chronic heart failure admitted to this hospital from January 2021 to July 2022.They were divided into control group and observation group according to the random number table method,35 cases in each group.Both groups were treated with routine symptomatic treatment.On this basis,the control group was treated with Benazepril,while the observation group was treated with Metoprolol on the basis of that of the control group.The clinical efficacy,the levels of laboratory indexes[serum fibroblast growth factor 23(FGF23),plasma N-terminal B-type natriuretic peptide(NT-proBNP)],the levels of cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular endsystolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)],the blood pressure,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 94.29%(33/35),which was higher than 71.43%(25/35)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure,diastolic blood pressure,serum FGF23 and plasma NT-proBNP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the LVEF levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of LVEDD and LVESD in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Metoprolol combined with Benazepril in the treatment of the patients with essential hypertension and chronic heart failure can improve the total effective rate of treatment,improve the levels of cardiac function indexes and reduce the levels of laboratory indicators and blood pressure.Moreover,it is superior to single Benazepril treatment.