吡格列酮二甲双胍联合度拉糖肽治疗2型糖尿病患者的效果

Effects of Pioglitazone hydrochloride and Metformin hydrochloride tablets combined with Dulaglutide in treatment of patients with type 2 diabetes mellitus

目的:观察吡格列酮二甲双胍联合度拉糖肽治疗2型糖尿病(T2DM)患者的效果。方法:回顾性分析2021年10月至2022年10月该院收治的96例T2DM患者的临床资料,按照治疗方案不同将其分为对照组和观察组各48例。对照组予以度拉糖肽治疗,观察组在对照组基础上联合吡格列酮二甲双胍治疗,两组均持续治疗3个月。比较两组临床疗效,治疗前后血糖指标[空腹血糖(FBG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)]水平、血脂指标[高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)]水平、血管内皮功能指标[脂联素(ADPN)、内皮素-1(ET-1)、一氧化氮(NO)]水平,以及不良反应发生率。结果:观察组治疗总有效率为93.75%(45/48),高于对照组的79.17%(38/48),差异有统计学意义(P<0.05);治疗后,观察组FBG、2hPG、HbA1c、TG、LDL-C、TC、ET-1水平均低于对照组,差异有统计学意义(P<0.05);观察组HDL-C、ADPN、NO水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:吡格列酮二甲双胍联合度拉糖肽治疗T2DM患者可提高治疗总有效率,降低血糖指标水平,改善血脂指标和血管内皮功能指标水平,效果优于单纯度拉糖肽治疗。

Objective:To observe effects of Pioglitazone hydrochloride and Metformin hydrochloride tablets combined with Dulaglutide in treatment of patients with type 2 diabetes mellitus(T2DM).Methods:The clinical data of 96 patients with T2DM admitted to this hospital from October 2021 to October 2022 were retrospectively analyzed.They were divided into control group and observation group according to different treatment schemes,48 cases in each.The control group was treated with Dulaglutide,while the observation group was treated with Pioglitazone hydrochloride and Metformin hydrochloride tablets on the basis of that of the control group.Both groups were treated for 3 months.The clinical efficacy,the blood glucose index levels[fasting blood glucose(FBG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],the blood lipid index levels[high-density lipoprotein cholesterol(HDL-C),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC)],the vascular endothelial function indexes[adiponectin(ADPN),endothelin-1(ET-1),nitric oxide(NO)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 93.75%(45/48),which was higher than 79.17%(38/48)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FBG,2hPG,HbA1 c,TG,LDL-C,TC and ET-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of HDL-C,ADPN and NO in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Pioglitazone hydrochloride and Metformin hydrochloride tablets combined with Dulaglutide in the treatment of the T2DM patients can improve the total effective rate of treatment,reduce the levels of blood glucose indexes and improve the levels of blood lipid indexes and vascular endothelial function indexes.Moreover,it is superior to single Dulaglutide treatment.