复方甘草酸苷联合多烯磷脂酰胆碱治疗酒精性肝炎患者的效果

Effects of Compound glycyrrhizin combined with Polyene phosphatidylcholine in treatment of patients with alcoholic hepatitis

目的:观察复方甘草酸苷联合多烯磷脂酰胆碱治疗酒精性肝炎患者的效果。方法:回顾性分析2021年11月至2022年12月杞县人民医院收治的90例酒精性肝炎患者的临床资料,按照治疗方式不同将其分为对照组和观察组各45例。对照组予以多烯磷脂酰胆碱治疗,观察组在对照组基础上联合复方甘草酸苷治疗,两组均持续治疗1个月。比较两组临床疗效,治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转移酶(GGT)、总胆红素(TBIL)]水平、肝纤维化指标[层粘连蛋白(LN)、Ⅳ型胶原蛋白(Ⅳ-C)、Ⅲ型前胶原蛋白(PCⅢ)、透明质酸(HA)]水平、氧化应激指标[谷胱甘肽过氧化物酶(GHT-Px)、超氧化物歧化酶(SOD)、丙二醛(MDA)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.56%(43/45),高于对照组的77.78%(35/45),差异有统计学意义(P<0.05);观察组ALT、AST、GGT、TBIL、HA、LN、PCⅢ、Ⅳ-C、MDA水平均低于对照组,差异有统计学意义(P<0.05);观察组GSH-Px、SOD水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:复方甘草酸苷联合多烯磷脂酰胆碱治疗酒精性肝炎患者可提高治疗总有效率,改善氧化应激指标水平,降低肝功能指标和肝纤维化指标水平,效果优于单纯多烯磷脂酰胆碱治疗。

Objective:To observe effects of Compound glycyrrhizin combined with Polyene phosphatidylcholine in treatment of patients with alcoholic hepatitis.Methods:The clinical data of 90 patients with alcoholic hepatitis admitted to Qi County People’s Hospital from November 2021 to December 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,45 cases in each.The control group was treated with Polyene phosphatidylcholine,while the observation group was treated with Compound glycyrrhizin on the basis of that of the control group.Both groups were treated for 1 month.The clinical efficacy,the liver function index levels[alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transferase(GGT),total bilirubin(TBIL)],the liver fibrosis index levels[laminin(LN),type Ⅳ collagen(IV-C),type Ⅲ procollagen(PCⅢ),hyaluronic acid(HA)],the oxidative stress index levels[glutathione peroxidase(GHT-Px),superoxide dismutase(SOD),malondialdehyde(MDA)],and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 95.56%(43/45),which was higher than 77.78%(35/45)in the control group,and the difference was statistically significant(P<0.05).The levels of ALT,AST,GGT,TBIL,HA,LN,PCⅢ,Ⅳ-C and MDA in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of GSH-Px and SOD in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound glycyrrhizin combined with Polyene phosphatidylcholine can improve the total effective rate of treatment,improve the levels of oxidative stress indexes,and reduce the levels of liver function indexes and liver fibrosis indexes in the patients with alcoholic hepatitis.Moreover,it is superior to single Polyene phosphatidylcholine treatment.