地衣芽孢杆菌治疗小儿功能性腹痛的效果

Effects of Bacillus licheniformis in treatment of functional abdominal pain in children

目的:观察地衣芽孢杆菌治疗小儿功能性腹痛的效果。方法:选取2021年1月至2023年1月该院收治的60例功能性腹痛患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各30例。对照组给予常规药物(多潘立酮混悬液+消旋山莨菪碱片)治疗,观察组在对照组基础上联合地衣芽孢杆菌颗粒治疗。比较两组腹痛次数、腹痛程度评分、临床疗效、临床症状改善指标水平、不良反应发生率及复发率。结果:治疗后,两组腹痛次数、腹痛程度评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为100.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);观察组情绪改善时间、食欲改善时间、排便改善时间和睡眠改善时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);3个月后,观察组复发率为6.67%,低于对照组的30.00%,差异有统计学意义(P<0.05)。结论:地衣芽孢杆菌治疗小儿功能性腹痛,可改善腹痛症状,提高临床疗效,缩短症状改善时间,降低复发率,效果优于常规治疗。

Objective:To observe effects of Bacillus licheniformis in treatment of functional abdominal pain in children.Methods:A prospective study was conducted on 60 children with functional abdominal pain admitted to this hospital from January 2021 to January 2023.They were divided into control group and observation group according to the random number table method,30 cases in each group.The control group was treated with conventional drugs(Domperidone suspension+Raceanisodamine tablets),while the observation group was treated with Bacillus licheniformis granules on the basis of that of the control group.The number of abdominal pain,the abdominal pain score,the clinical efficacy,the clinical improvement index levels,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:After the treatment,the numbers of abdominal pain and the abdominal pain degree scores in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 100.00%,which was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).The emotional improvement time,the appetite improvement time,the defecation improvement time and the sleep improvement time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 3 months,the recurrence rate of the observation group was 6.67%,which was lower than 30.00%of the control group,and the difference was statistically significant(P<0.05).Conclusions:Bacillus licheniformis in the treatment of functional abdominal pain in the children can improve the symptoms of abdominal pain,improve the clinical efficacy,shorten the symptom improvement time,and reduce the recurrence rate.Moreover,it is superior to conventional treatment.