摘要
间质性肺疾病(interstitial lung disease,ILD)病因复杂多样,药物性间质性肺疾病(drug-induced interstitial lung disease,DIILD)又称药物性肺炎或药物性肺毒性,受抗癌药物作用机理及不同癌症发病率等多方面影响,不同种类抗癌药物诱发DIILD发生率存在差异,并且某些抗癌药物相关DIILD的发生常预示着预后不良甚至高死亡率。然而与药物性肝肾损伤相比,药物性肺炎未引起足够的重视。目前多部专家共识对抗癌药物相关DIILD的诊断及治疗提出指导,但抗癌药物种类繁多,且治疗方案受到肿瘤类型的影响,某一类药物诱发DIILD的具体特征有待进一步阐明。本文对已发表的抗癌药物相关DIILD流行病学及危险因素进行综述,以期为进一步认识此类药物的不良事件提供帮助。
The etiology of interstitial lung disease(ILD)is complex and varied.Drug-induced interstitial lung disease(DIILD)is also known as drug-induced pneumonia or drug-induced pulmonary toxicity,influenced by the mechanism of action of anticancer drugs and the morbidity of different cancers,the incidence of DIILD induced by different anticancer drugs is different,and the occurrence of DIILD associated with some anticancer drugs often predicts poor prognosis and even high mortality.However,compared with drug-induced liver and kidney injury,drug-induced pneumonia has not been paid enough attention.At present many expert consensus provides guidance for the diagnosis and treatment of DIILD related to anticancer drugs,whereas there are many kinds of anticancer drugs,and the therapeutic regimen is affected by the type of tumor.The specific characteristics of DIILD induced by a certain class of drugs need to be further clarified.In this paper,the epidemiology and risk factors of DIILD related to anticancer drugs were reviewed in order to provide help for further understanding of this adverse drug event.
作者
李明宇(综述)
高丽(审校)
Mingyu Li;Li Gao(Department of Geriatric Medical Center,Inner Mongolia People’s Hospital,Hohhot 010017,China;Inner Mongolia Medical University,Hohhot 010000,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2023年第16期850-854,共5页
Chinese Journal of Clinical Oncology
基金
国家老年疾病临床医学研究中心项目(编号:NCRCG-PLAGH-20230013)资助。
关键词
抗癌药物
间质性肺疾病
药物性间质性肺疾病
anticancer drugs
interstitial lung disease(ILD)
drug-induced interstitial lung disease(DIILD)