真菌性角膜炎治疗研究进展

Advances in the treatment of fungal keratitis

目前真菌性角膜炎(fungal keratitis,FK)的诊治困难在于疾病的早期诊断、抗真菌药物的生物毒性以及药物在眼部的生物利用度较低等。随着近年对FK治疗研究的不断深入,新的药物治疗计划及药物剂型(原位凝胶、双功能壳聚糖衍生物平台、金属离子及天然抗真菌成分等)被提出,并且疗效在感染FK的动物模型中得到验证。手术治疗方面,角膜移植术及光动力学疗法是目前临床较常用的治疗方式,同时新提出的低温等离子射频消融术及无缝线角膜黏合在控制感染及安全性上更显优势。

The current difficulties in the diagnosis and treatment of Fungal keratitis(FK)are not easily detected in early diagnosis of the disease,the biotoxicity of antifungal drugs and the low bioavailability of the drugs in the eye,etc.With more research on FK treatment in recent years,new drugs and drug carrier formulations have been proposed and their efficacy has been verified in animal models of FK infection.Regarding surgical treatment,corneal transplantation,and photodynamic therapy are the more commonly used treatment modalities,while the newly proposed low-temperature plasma surgical system is more advantageous in the control of infection and safety in the treatment of FK.