微生态调节剂对小儿轮状病毒性肠炎的临床干预效果分析

Clinical effect of microecological modulator on rotavirus enteritis in children

目的探讨双歧杆菌三联活菌散(培菲康)联合复方嗜酸乳杆菌片辅助治疗小儿轮状病毒性肠炎的效果。方法选取2020年8月至2022年9月于广德市人民医院治疗的轮状病毒性肠炎患儿120例,按照随机数字表法将患儿分为对照组、培菲康组和联合菌组,每组40例。对照组给予常规补液治疗,培菲康组在常规治疗基础上加用培菲康,联合菌组在常规治疗基础上加用培菲康和复方嗜酸乳杆菌片,治疗1~5天后比较3组临床治疗效果、肠道益生菌及致病菌改变、肠道通透性功能和血清炎性因子变化。结果联合菌组治疗总有效率高于培菲康组和对照组(P<0.05)。联合菌组患儿的临床症状(腹泻、腹痛、呕吐及脱水)消失时间明显早于对照组和培菲康组(P<0.05)。3组肠道双歧杆菌、嗜酸乳杆菌和粪肠球菌均升高,联合菌组升高比例高于培菲康组和对照组(P<0.05);3组肠道大肠杆菌和产气荚膜杆菌均降低,联合菌组降低程度高于培菲康组和对照组(P<0.05)。联合菌组血清D乳酸、二胺氧化酶、内毒素及炎性因子(TNF-α、IL-1β、IL-6及IL-17)水平降低幅度高于培菲康组和对照组(P<0.05)。结论在常规治疗基础上联合培菲康、复方嗜酸乳杆菌片可提高对小儿轮状病毒的治疗效果。

Objective To investigate the effect of Bifidobacterium Triple Viable Powder(Peifeikang)combined with compound Lactobacillus acidophilus tablets in the adjuvant treatment of rotavirus enteritis in children.Methods A total of 120 children with rotavirus enteritis treated in Guangde People's Hospital from August 2020 to September 2022 were included and randomly divided into control group,Peifeikang group and combined bacteria group according to random number table method,with 40 cases in each group.The control group was given conventional rehydration treatment,the Peifeikang group was given Peifeikang preparation on the basis of conventional treatment,and the combined bacteria group was given probiotic preparations such as Peifeikang and compound Lactobacillus acidophilus tablets on the basis of conventional treatment.After 5 days of treatment,the clinical therapeutic effect,the changes of intestinal probiotics and pathogenic bacteria,intestinal permeability function and serum inflammatory factors were compared among the three groups.Results After treatment,the total effective rate of the combined bacteria group was significantly higher than that of the Peifeikang group and the control group(P<0.05).The disappearance time of clinical symptoms(diarrhea,abdominal pain,vomiting and dehydration)in the combined bacteria group was significantly earlier than that in the control group and the Pefikang group.Among the intestinal flora detected,Bifidobacterium intestinalis,Lactobacillus acidophilus and Enterococcus faecalis were increased in the three groups,and the increased proportion in the combined bacteria group was higher than that in the Peifeikang group and the control group(P<0.05).Enteric Escherichia coli and Perfringens were decreased in all three groups,and the reduction degree of the combined bacteria group was higher than that of the Peifeikang group and the control group(P<0.05).The decrease of serum D-lactic acid,DAO,ET and inflammatory factors(TNF-?,IL-1β,IL-6 and IL-17)levels in the combined bacteria group was higher than that in the Peifeikang group and the control group(P<0.05).Conclusion On the basis of conventional treatment,combination of Peifeikang and compound Lactobacillus acidophilus tablets can improve the therapeutic effect of rotavirus in children.