易栓症与妊娠期血栓栓塞性疾病的关系、筛查及预防研究

Research on the relationship,screening and prevention of thrombophilia and thromboembolic disease in pregnancy

易栓症是指存在各种遗传性或获得性因素而导致的血栓栓塞风险增加的病理状态。妊娠期特有的凝血潜能增加、抗凝血活性降低导致妊娠本身处于生理性高凝状态,当合并患有易栓症时,会增加发生妊娠期血栓栓塞性疾病的风险。目前对于易栓症与妊娠期并发症的相关性仍存在争议,本文主要论述易栓症与妊娠期血栓栓塞性疾病之间的关系以及筛查和预防策略。

Thrombophilia refers to a pathological condition with an increased risk of thromboembolism due to the presence of various inherited or acquired factors,an increased coagulation potential unique to pregnancy,and a reduced anticoagulant activity resulting in the pregnancy itself being physiologically hypercoagulable,which,when combined with thrombophilia,increases the risk of thromboembolic disease during pregnancy.There is still controversy about the association of thrombophilia with complications during pregnancy,and this article mainly addresses the association between thrombophilia and thromboembolic disease of pregnancy.