中链甘油三酯对阿尔茨海默病影响的研究进展

Progress in the impact of medium-chain triglyceride in Alzheimer's disease

为了研究中链甘油三酯(MCT)对延缓阿尔茨海默病(AD)发生的有效性,分析了MCT在体内的代谢过程,综述了MCT对AD的作用机制,介绍了MCT食品针对AD的应用状况。MCT可能通过抗氧化作用、抗炎作用、减少脑淀粉样蛋白-β沉积、保护线粒体功能以及改善脑能量代谢等方面延缓AD的发生。目前已有基于MCT的食品用于缓解AD患者的病情,如Axona■(由MCT组成)、Ketonformula■(基于MCT配方的奶粉)等。MCT对AD有一定的改善作用,在日常饮食中合理运用MCT可以延缓AD发生。

In order to investigate the effectiveness of medium-chain triglyceride(MCT)in delaying the occurrence of Alzheimer's disease(AD),the metabolic process of MCT in vivo was analysed,the action mechanism of MCT on AD was reviewed,and the application status of MCT foods for AD was presented.MCT may delay the occurrence of AD through antioxidant effects,anti-inflammatory effects,reduction of brain amyloid-βdeposition,protection of mitochondrial function and improvement of brain energy metabolism.MCT has been used to alleviate the condition of patients with AD,such as Axona ■(composed of MCT)and Ketonformula ■(a milk powder based on MCT),etc.MCT has been shown a beneficial effect on AD,and can be used in the daily diet to delay the occurrence of AD.