摘要
慢性肝病是我国高发且备受关注的公共卫生安全问题,易导致肝结构和功能不可逆的改变。在慢性肝病发生时会出现多种代谢异常,其中谷氨酰胺代谢在慢性肝病病理进展中发挥重要作用。本文阐述了IL-6/STAT3/c-myc、PI3K/AKT/mTOR、ERK/NGFI-B/GLS1、Hedgehog-YAP和APC/C-Cdh1信号通路对谷氨酰胺代谢的调控机制,以及谷氨酰胺代谢对酒精性肝病、酒精性脂肪性肝病、肝纤维化和肝癌等慢性肝病的影响,以期为慢性肝病的基础研究以及新药研发提供新的视野。
Chronic liver disease(CLD)is a public health issue with high incidence,and it tends to impose an irreversible change on the structure and function of the liver.Its occurrence is accompanied by several kinds of metabolic abnormality,and glutamine metabolism plays an important role in the pathological progress of CLD.The regulation mechanism of signal pathways such as IL-6/STAT3/c-myc,PI3K/AKT/mTOR,ERK/NGFI-B/GLS1SIRT3/HIF-1α/GLS,Hedgehog-YAP and APC/C-Cdh1 for glutamine metabolism as well as the impact of glutamine metabolism on alcoholic liver disease,alcoholic fatty liver disease,fibrosis of liver,hepatoma and other chronic liver diseases are illustrated in this article,with the hope of providing a new vision to the fundamental research of CLD and to drug discovery.
作者
江周影
梁诗雨
赵铁建
王佳慧
郑洋
JIANG Zhouying;LIANG Shiyu;ZHAO Tiejian;WANG Jiahui;ZHENG Yang(Department of Physiology,School of Basic Medicine,Guangxi University of Chinese Medicine,Nanning 530222,Guangxi Zhuang Autonomous Region,China;Department of Medicine,Faculty of Chinese Medicine Science,Guangxi University of Chinese Medicine,Nanning 530222,Guangxi Zhuang Autonomous Region,China)
出处
《解放军医学院学报》
CAS
北大核心
2023年第7期800-805,共6页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金项目(82204755,81960751)
广西自然科学基金青年基金项目(2020GXNSFBA297094,2023GXNSFBA026274)
广西中青年教师科研基础能力提升项目(2022KY1667)
广西中医药大学赛恩斯新医药学院自治区级创新创业训练项目(S202213643005)
广西中医药大学青年基金(2022QN008)
广西中医药大学赛恩斯新医药学院科研项目(2022MS008,2022QJ001)。