谷氨酰胺代谢调控慢性肝病作用机制的研究进展

Research advances in glutamine metabolism in regulating chronic liver disease

慢性肝病是我国高发且备受关注的公共卫生安全问题,易导致肝结构和功能不可逆的改变。在慢性肝病发生时会出现多种代谢异常,其中谷氨酰胺代谢在慢性肝病病理进展中发挥重要作用。本文阐述了IL-6/STAT3/c-myc、PI3K/AKT/mTOR、ERK/NGFI-B/GLS1、Hedgehog-YAP和APC/C-Cdh1信号通路对谷氨酰胺代谢的调控机制,以及谷氨酰胺代谢对酒精性肝病、酒精性脂肪性肝病、肝纤维化和肝癌等慢性肝病的影响,以期为慢性肝病的基础研究以及新药研发提供新的视野。

Chronic liver disease(CLD)is a public health issue with high incidence,and it tends to impose an irreversible change on the structure and function of the liver.Its occurrence is accompanied by several kinds of metabolic abnormality,and glutamine metabolism plays an important role in the pathological progress of CLD.The regulation mechanism of signal pathways such as IL-6/STAT3/c-myc,PI3K/AKT/mTOR,ERK/NGFI-B/GLS1SIRT3/HIF-1α/GLS,Hedgehog-YAP and APC/C-Cdh1 for glutamine metabolism as well as the impact of glutamine metabolism on alcoholic liver disease,alcoholic fatty liver disease,fibrosis of liver,hepatoma and other chronic liver diseases are illustrated in this article,with the hope of providing a new vision to the fundamental research of CLD and to drug discovery.