TMEM家族在乳腺癌中的研究进展

Research advances in novelty roles of transmembrane protein family in breast cancer

跨膜蛋白(transmembrane protein,TMEM)基因家族广泛参与细胞膜结构的组成,如内质网、溶酶体和高尔基体。研究发现TMEM蛋白在乳腺癌的发生发展过程中发挥重要作用,具有促癌和(或)抑癌的双重功能。TMEM不仅参与调控乳腺癌细胞的增殖、侵袭和迁移等,同时与化疗耐药有关。因此,更好地表征TMEM家族成员在乳腺癌中的表达情况、临床意义和预后价值,探索其功能可以为肿瘤的预防和治疗提供新的思路。

Transmembrane proteins(TMEM)family is widely involved in the structure of the biological membrane,including endoplasmic reticulum,lysosomes and Golgi apparatus.TMEM proteins are reported to play a pivotal role in the development of breast cancer,which have also endowed with dual functions of oncogene and/or suppressor.TMEM is not only involved in regulating the proliferation,invasion and migration of breast cancer cells,but also associated with chemotherapy resistance.Therefore,understandings of the characteristics of the expression,clinical significance and prognostic value of TMEM family members in breast cancer can provide new insights to tumor prevention and treatment.