功能磁共振成像技术在针灸治疗抑郁症中枢机制研究中的应用进展

Application of fMRI in the study of central mechanism of acupuncture and moxibustion in the treatment of depression

抑郁症是一种由各种原因引起的以显著而持久的心境低落为主要临床特征的情感性精神障碍,属传统医学中“郁证”范畴。临床上针灸治疗抑郁症疗效显著,国内外对其中枢机制的研究众多,但由于研究设计方法的差异,尚未形成统一标准。功能MRI(functional MRI,fMRI)技术的出现在脑功能定位领域占有一席之地,为针灸治疗抑郁症中枢机制的研究提供可靠技术支持。本文对fMRI的应用、抑郁症相关脑功能网络异常研究进展以及经针灸治疗后抑郁症患者脑功能网络改善状况的研究进展作一综述,以期为研究针灸治疗抑郁症的潜在机制提供新思路。

Depression is a kind of affective disorder caused by various reasons,which is mainly characterized by significant and lasting depression.It belongs to the category of"depression syndrome"in traditional medicine.Acupuncture is effective in the treatment of depression in clinic,and there are many studies on its central mechanism at home and abroad,but due to the differences in research design methods,a unified standard has not been formed.The emergence of functional MRI(fMRI)has a place in the field of brain functional localization,which provides reliable technical support for the study of the central mechanism of acupuncture in the treatment of depression.This article reviews the application of fMRI,the research progress of abnormal brain function network related to depression and the improvement of brain function network in patients with depression after acupuncture treatment,in order to provide new ideas for studying the potential mechanism of acupuncture treatment of depression.