定量磁化率成像技术在认知功能障碍中的研究进展

Research progress of quantitative susceptibility mapping in cognitive impairment

认知功能障碍由多种疾病引发,以往的研究已证明脑内铁的异常沉积和认知功能障碍之间存在一定的关联。定量磁化率成像技术(quantitative susceptibility mapping,QSM)是一种新的成像技术,可以定量检测组织中磁性物质,为研究阿尔茨海默病、帕金森病、2型糖尿病、血管性认知障碍等多种疾病所致认知功能障碍与脑内铁沉积相关性提供了可行的方法。本文对近几年QSM技术与认知功能障碍的最新相关研究进展进行综述,从认知功能障碍病因、相应脑内铁沉积部位、和影像相关表现等方面对QSM技术在研究认知功能障碍中的应用价值进行分析,旨在为早期无创性评估患者病情进展、制订治疗方案提供客观的影像依据。

Cognitive impairment is caused by various diseases,and previous studies have shown a certain correlation between abnormal iron deposition in the brain and cognitive impairment.Quantitative susceptibility mapping(QSM)is a new imaging technique that can quantitatively detect magnetic substances in tissues,providing a feasible method for studying the correlation between cognitive impairment and iron deposition in the brain caused by Alzheimer's disease,Parkinson's disease,Diabetes mellitus type 2,vascular cognitive impairment and other diseases.This article provided a review of the latest research progress on QSM technology and cognitive impairment in recent years.It analyzed the application value of QSM technology in the study of cognitive impairment from the aspects of the etiology of cognitive impairment,corresponding brain iron deposition sites,and imaging related manifestations.The aim is to provide objective imaging basis for non-invasive assessment of patient progress and formulation of treatment plans in the early stage.