MRI影像组学在肝细胞癌疗效评估的研究进展

Research progress of MRI radiomics in the evaluation of curative effect of hepatocellular carcinoma

肝细胞癌(hepatocellular carcinoma,HCC)是全球第六大常见恶性肿瘤,也是与癌症相关死亡的第四大原因。早期精准预测疗效对患者的预后至关重要,但多数评估治疗疗效的指标基于术后病理活检,这无助于术前决策制订。MRI影像组学能够通过医学图像中灰度的空间分布和关系来量化肿瘤异质性,定量地提取图像微观特征,在术前达到明确肿瘤病理学缓解程度和预测肿瘤治疗效果的目的,满足后续个性化治疗方案制订的需求。本文就MRI影像组学在HCC治疗疗效评估的研究进展进行综述,以拓展基于MRI影像组学在HCC预测复发、评估疗效方面的应用价值,为制订最佳临床治疗方案提供新思路。

Hepatocellular carcinoma(HCC)is the sixth most common malignant tumor and the fourth leading cause of cancer-related mortality worldwide.Early and accurate prediction of therapeutic effect is very important for the prognosis of patients,but most indexes for evaluating therapeutic effect are based on postoperative pathological puncture,which is not helpful for preoperative decision-making.MRI radiomics can quantify tumor heterogeneity through the spatial distribution and relationship of gray levels in medical images and quantitatively extract the microscopic characteristics of images in order to clarify the degree of tumor pathological remission,predict the therapeutic effect of tumors before operations,and meet the needs of subsequent individualized treatment plan formulation.This paper reviews the research progress of MRI imaging in the evaluation of the therapeutic effect of HCC in order to expand the application value of MRI imaging in predicting recurrence and evaluating the therapeutic effect of HCC and to provide new ideas for formulating the best clinical treatment plan.