小细胞肺癌脑转移机制及预测指标的研究进展

Research progress about mechanism and predictor of brain metastases in small cell lung cancer

小细胞肺癌(small cell lung cance,SCLC)是一种特殊类型的肺癌,侵袭性强,转移部位广泛,半数以上患者会在疾病进程中发生脑转移(brain metastases,BM)。SCLC中枢神经系统转移通常在已形成颅内病灶后依靠影像学检测确诊,且目前针对SCLC-BM的治疗效果有限,预后差。描述SCLC-BM发生机制的相关研究显示相关基因、信号通路、循环标志物、细胞因子及其他功能蛋白质发生改变,为预测及预防脑转移提供思路。

Small cell lung cancer(SCLC)is a highly aggressive and widespread subtype of lung cancer.Throughout the course of this cancer type,over half of SCLC patients will develop brain metastases(BM),contributing to its formidable clinical challenge.Central nervous system metastases of SCLC patients are typically confirmed through imaging detection once intracranial lesions have formed.Regrettably,the current treatment options for SCLC-BM yield limited effectiveness,resulting in a bleak prognosis.Recent studies elucidating the mechanism underlying SCLC-BM have identified alterations in related genes,signal pathways,biomarkers,cytokines,and functional proteins.These insights not only provide avenues for predicting disease progression but also offer potential strategies for preventive interventions.