天然产物蟛蜞菊内酯的研究进展

Research Progress of Natural Product Wedelolactone

天然产物在自然界中广泛存在,在医药、食品、保健品以及美妆行业有着广泛的应用。蟛蜞菊含有多种化学成分且富含各种人体所必需的氨基酸、维生素及多种微量元素。由于天然产物提取困难且含量少导致大量的活性产物不能投入到真正的研发之中,阻碍了人类科学的发展。蟛蜞菊内酯是一种从蟛蜞菊和旱莲草中提取出来的呋喃香豆素类小分子化合物,具有多重的生物活性,故天然产物蟛蜞菊内酯的全合成应运而生,不仅推动了医药行业的发展,同时也带动了食品、保健品的发展。

Natural products are widely found in nature and have a wide range of applications in the pharmaceutical,food,health care and beauty industries.Wedelia contains many chemical components and is rich in various essential amino acids,vitamins and trace elements.The difficulty of extracting natural products and their low content have prevented a large number of natural products to be putted into research and development,hindering the development of human science.Wedelolactone is a small molecule compound of furanocoumarins extracted from Wedelia and Drynaria,which has multiple biological activities.Therefore,the total synthesis of natural product wedelolactone came into being,and the combination of the two not only promoted the development of the pharmaceutical industry,but also led to the development of food and health products.