摘要
Nitroanilines are important building blocks in pharmaceuticals,materials and dyes.Nitration methods for anilines under mild conditions are highly desired.Herein,we report a photochemical method for the nitration of anilines bearing various protecting groups by 5-methyl-1,4-dinitroimidazole as a new type of nitro source.This method is light-controlled and proceeds under mild reaction conditions with high efficiency.Fmoc-,Ts-and alkyl-protected anilines are all well nitrated with good functional group tolerance.
基金
supported by NSF of China(Grant 21922703 and 91953112 to H.W.)
the Natural Science Foundation of Jiangsu Province(Grant BK20190004 and BK20202004)
National Key R&D Program of China(2019YFA0905800).
