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铁死亡在脓毒症相关脑病中的研究进展

Progress in ferroptosis in sepsis-associated encephalopathy
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摘要 综述脓毒症相关脑病(sepsis-associated encephalopathy,SAE)中铁死亡的发生机制及总结现有铁死亡相关药物的应用,并对靶向铁死亡的临床转化应用前景进行展望,为SAE的预防和治疗提供新的理论依据及策略。SAE是一种全身感染引起的认知障碍和急性中枢神经系统功能障碍,是脓毒症的一种严重且常见的并发症,它由缺氧、血脑屏障破坏、神经递质失衡、胶质细胞激活、轴突和神经元缺失引起的炎症。铁死亡发生是因为细胞内铁过载,使铁依赖的脂质代谢异常,氧化还原平衡被破坏,过氧化物蓄积而最终诱发细胞死亡。研究SAE发病机制中的铁死亡,论述抑制铁死亡可通过减少血脑屏障破坏和神经异常、认知障碍来预防SAE。 To review the mechanism of ferroptosis in sepsis-related encephalopathy(SAE),and summarize the application of existing ferroptosis related drugs,and to prospect the clinical translational application of targeted ferroptosis,in order to provide a new theoretical basis and strategy for the prevention and treatment of SAE.SAE,a cognitive impairment and acute CNS dysfunction due to systemic infection,is a serious and common complication of sepsis,with inflammation caused by hypoxia,blood-brain barrier disruption,neurotransmitter imbalance,glial cell activation,and axonal and neuronal loss.Ferroptosis occurs as a result of intracellular iron overload,which leads to abnormalities in iron-dependent lipid metabolism,disruption of redox homeostasis,and accumulation of peroxides,ultimately inducing cell death.To study ferroptosis in the pathogenesis of SAE and conclude that inhibiting ferroptosis can prevent SAE by reducing blood-brain barrier disruption,neurological abnormalities and cognitive impairment.
作者 吴晓颖 李岩(审校) WU Xiaoying;LI Yan(Department of Emergency,Affiliated Shanghai Municipal Fourth People's Hospital,Tongji University,Shanghai,200434,China)
出处 《临床急诊杂志》 CAS 2023年第8期437-442,共6页 Journal of Clinical Emergency
关键词 铁死亡 脓毒症相关脑病 血脑屏障 脑功能障碍 星形胶质细胞 ferroptosis sepsis-related encephalopathy blood-brain barrier brain dysfunction astrocytes
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