索利那新联合坦索罗辛对良性前列腺增生症患者并发膀胱过度活动症的改善作用

The Improvement Effect of Solifenacin Combined with Tamsulosin on Overactive Bladder in Patients with Benign Prostatic Hyperplasia

目的探讨索利那新联合坦索罗辛对良性前列腺增生症(benign prostatic hyperplasia,BPH)患者并发膀胱过度活动症(overactive bladder,OAB)的改善作用。方法选择2020年1月—2022年12月庄河市中心医院收治的BPH合并OAB患者100例,随机分为对照组和观察组各50例。两组均进行生活方式干预,对照组采用坦索罗辛进行治疗,观察组在其基础上联合索利那新治疗,比较两组治疗后的排尿动力学改善情况、症状缓解情况及药物不良反应发生情况。结果治疗后,观察组排尿量、平均尿流率、最大尿流率、最大膀胱压测定容量、膀胱顺应性大于对照组,而膀胱残余尿量小于对照组,差异有统计学意义(P<0.05);观察组储尿期症状评分、排尿期症状评分和膀胱过度活动症评价量表评分小于对照组,差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论在应用坦索罗辛基础上加用索利那新,可以进一步改善BPH并发OAB患者的排尿功能和减轻不良症状,而且并未增加药物不良反应发生风险。

Objective To explore the improvement effect of solifenacin combined with tamsulosin on overactive bladder(OAB)in patients with benign prostatic hyperplasia(BPH).Methods A total of 100 patients with BPH combined with OAB admitted to Zhuanghe Central Hospital from January 2020 to December 2022 were randomly divided into a control group and an observation group,with 50 patients in each group.Both groups received lifestyle interventions,while the control group received treatment with tamsulosin,while the observation group received solifenacin additionally.The improvement of urination dynamics,symptom relief,and occurrence of adverse drug reactions between the two groups after treatment were compared.Results After treatment,the observation group had significantly higher voiding volume,average flow rate,maximum flow rate,maximum bladder Volume-pressure,and bladder compliance than the control group,while the residual urine volume in the bladder was significantly lower than the control group(P0.05).Conclusion On the basis of the application of tamsulosin,the addition of solifenacin can further improve urinary function and alleviate adverse symptoms in BPH patients with OAB,and do not increasethe risk of adverse drug reactions.