肿瘤微环境对肿瘤细胞上皮-间质转化的多重作用研究进展

Multiple roles of tumor microenvironment in epithelial-mesenchymaltransition of tumor cells:a review

肿瘤细胞的转移为肿瘤治疗带来了巨大的困难。肿瘤微环境是肿瘤发展所处的复杂而丰富的多细胞环境,其中肿瘤相关的免疫细胞会诱导肿瘤细胞发生上皮-间质转化(EMT),增强肿瘤细胞的侵袭性和运动性,促使肿瘤细胞转移,而经历EMT的肿瘤细胞又会分泌细胞因子等物质,重组肿瘤微环境。EMT和肿瘤微环境之间互相作用,加重肿瘤的侵袭和转移。本文收集2015—2023年有关肿瘤微环境与肿瘤细胞EMT的研究文献,就肿瘤微环境对肿瘤EMT的作用进行综述,为肿瘤转移机制研究和抗肿瘤药物研发提供依据。

Metastasis of tumor cells poses great difficulties for tumor therapy.Tumor microenvironment is a complex and rich multicellular environment for the development of tumors,in which tumor-associated immune cells induce tumor cells to undergo epithelial-mesenchymal transition(EMT)which enhances the invasiveness and motility of tumor cells and prompts tumor cells to metastasize,and tumor cells undergoing EMT secrete cytokines and other substances to reor⁃ganize the tumor microenvironment.The interaction between EMT and the tumor microenvironment aggravate tumor inva⁃sion and metastasis.This paper collects research literature on tumor microenvironment and EMT of tumor cells from 2015 to 2023,and reviews the role of tumor microenvironment in tumor EMT,providing the basis for research into tu⁃mor metastasis mechanism and development of anti-tumor drugs.