氧连接的N-乙酰葡糖胺修饰在缺血性疾病损伤中的作用研究进展

Research progress on the role of O-linkedβ-N-acetylglucosamine modification in ischemic disease injury

氧连接的N-乙酰葡糖胺(O-linkedβ-N-acetylglucosamine,O-GlcNAc)修饰是一种在细胞中广泛存在的蛋白质翻译后修饰方式,在相关酶的作用下,将N-乙酰氨基葡萄糖可逆地连接于丝氨酸/苏氨酸末端。缺血性疾病损伤是由于组织血流灌注不足导致局部组织或细胞发生缺氧损伤的现象,其转归受到O-GlcNAc修饰的影响。文章通过综述O-GlcNAc修饰在缺血性疾病损伤中通过介导线粒体分裂、细胞凋亡、内质网应激、细胞能量代谢、自噬及氧化应激现象,从而预防和缓解缺血、缺氧对细胞的损伤,旨在探索O-GlcNAc修饰在缺血性损伤疾病中发挥的保护作用,并为后续临床上预防和降低缺血性疾病损伤提供新的治疗思路。

O-linkedβ-N-acetylglucosamine(O-GlcNAc)modification is a widely present protein post-translational modification that reversibly attaches N acetylglucosamine to serine/threonine terminals under the action of related enzymes.Ischemic disease injury is due to hypoxic damage of local tissues or cells due to insufficient blood perfusion of tissues,and its outcome is affected by O-GlcNAc modification.This article reviews the effects of O-GlcNAc modification in ischemic disease injury by mediating mitochondrial division,apoptosis,endoplasmic reticulum stress,cellular energy metabolism,autophagy and oxidative stress,aiming to explore the protective role of O-GlcNAc modification in ischemic injury diseases,and provide new therapeutic ideas for subsequent clinical prevention and reduction of ischemic disease injury.