铜催化的二醇类化合物对映选择性去对称化反应研究进展

Research Progress on Copper-Catalyzed Enantioselective Desymmetrization of Diols

二醇类化合物的对映选择性去对称化反应是合成复杂手性醇类化合物的重要方法,在药物化学、全合成和材料科学等学科中有着广阔的应用前景.铜催化剂相较于其他贵金属催化剂而言更加廉价易得,而且在反应中有着丰富的价态变化,因而近年来利用铜催化的策略实现二醇类化合物对映选择性去对称化的研究发展迅速.本综述依据二醇类化合物(内消旋二醇和前手性二醇)和反应类型的不同对该领域的研究进展进行归纳总结,并对未来发展做了简要展望.

Enantioselective desymmetrization of diols is an important method for the synthesis of complex enantioenriched alcohols,which has broad application prospects in medicinal chemistry,total synthesis,and materials science.In recent years,the use of copper catalysis to achieve diols’enantioselective desymmetrization has progressed rapidly because copper is inexpensive and readily available compared with other noble metal catalysts.Besides,copper undergoes a two-electron or single-electron transfer process in the catalytic cycle,and the rich oxidation states of copper provides the opportunity to solve some challenging problems.This review summarizes the research progress in this field according to the types of diols(meso diol and prochiral diol)and reactions together with a brief perspective.